What Is a Zeptosecond?

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In a football game on Sunday, the ball was intercepted and the defensive back started to run the ball back about 90 yards for a touchdown. Only he never made it. A wide receiver took off after him and caught him at about the 7-yard line. To watch it happen was simply amazing. He reached a speed of 22 mph.

That’s fast for a human being, but it’s a lifetime in physics. Scientists are trying to measure things in smaller blocks of time. They measured how long it took for a single particle of light to cross a single atom of hydrogen and came up with 247 zeptoseconds. A zeptosecond is a one after a decimal point followed by 20 zeros! That’s a trillionth of a billionth of a second. That’s relevant to science but not practical to us as humans.

However, time is something we should all think about. By breaking tasks into more discrete time intervals, we can focus on the individual elements that make up any task. I’ll give you a practical example in Thursday’s Memo. Until then, think about the tasks you perform and how many discrete intervals are involved in them. It will all make sense on Saturday.

What are you prepared to do today?

        Dr. Chet

Reference: DOI: 10.1126/science.abb9318.

Does Exercise Reduce COVID-19?

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I’ve written about fitness and COVID-19 before, but a recent post by a colleague got my attention. I had never been able to find any research that suggested people who are fitter would have less serious cases of COVID-19 or any upper respiratory infection for that matter. I thought maybe the scientific paper he used might provide an update. In addition, there were a couple of statements in the paper that caught me by surprise. Here’s what I found.

Exercise and Fatty Lungs

The paper suggested that if a person were overweight or obese, there could be an increase in fat cells in the lungs. As such, that could increase the available components such as fatty acids that could contribute to the cytokine storm in extreme cases of infection. I’d never heard that fat cells were found in the lungs, so I decided to dig deeper.

The paper referenced an article that talked about risk factors for severe cases of the COVID-19. They cited two studies. The first was a study on overweight diabetic rats. However, we’re not rats so we can’t assume the same applies to humans. The other article dealt only with obesity. The paper said that in a small study on humans, fat cells were found in the lung parenchyma where gas exchanges occur in the lung tissue.

I decided to check out that paper as well. It was a post-mortem examination of the lungs of normal-weight and overweight subjects who died from asthma and non-respiratory conditions. Researchers found fat cells in the cell walls of large structures greater than 6 mm in diameter but none in smaller areas. There was an increase in the fat cells and immune response cells in the fatal asthma cases in obese subjects. While interesting, it does not support the original article indicating fat cells in the lungs to any significant degree, because some obese subjects had none in their lung tissue.

Exercise and COVID-19

The rest of the paper discussed the benefits of exercise as it relates to weight loss, reducing cardiovascular disease, and improving metabolic systems, especially as related to type 2 diabetes. They talked about how every type of exercise improves the body enough to reduce comorbidities, and reducing comorbidities may lead to a better outcome if you get COVID-19.

The only misstatement was that exercise is a way to reduce a significant amount of body fat. It’s not; you also have to reduce your caloric intake to do that. But exercise can improve every organ system to respond better to challenges. That may help if one catches a severe case of COVID-19, so they got that right.

The Bottom Line

Exercise has been described this way: it would be the most prescribed medication in the world if it were in pill form. Based on this paper and the sum total of all the research on exercise and health, exercise can help you reduce your risk of a severe case of this or any virus, maybe not directly, but in helping you reduce your comorbidities. Move more and start today!

What are you prepared to do today?

        Dr. Chet

References:
1. Front. Physiol. doi.org/10.3389/fphys.2020.572718
2. Diabetes Metabolism. 2020. https://doi.org/10.1002/dmrr.3325.
3. Eur Resp J. 2019. 54:1900857; DOI: 10.1183/13993003.00857-2019

Research Update: COVID-19 on Surfaces

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There are hundreds of papers published every day on the COVID-19 virus. The range of topics borders on the incredible, so I decided to provide two updates based on a couple questions that I’ve gotten. The first is a simple one. How long does the virus live on surfaces? When does it become unable to infect us?

Using standardized procedures that exposed the surfaces to identical amounts of viable COVID-19 virus, researchers tested surfaces under a standard temperature of 68 degrees F and 35-40% humidity. They found the virus was detectable up to seven days on nitrile gloves, four days on chemical-resistant gloves, 21 days on plastic face shields and N95/N100 particulate respirators, and 14 days on stainless steel. All very nice, but how about what appears to be argued about most of the time: cotton masks? The viability of the virus on cotton was reduced within four hours of drying and by 24 hours, was not detectable at all. For a full explanation on the facts behind masks, check out the free Health Info on drchet.com: Cloth Masks: What the Research Says.

The researchers want to check out other materials used in personal protection devices, but the masks are most relevant to you and me. If we can’t wash them between uses, which will kill the virus, letting them dry completely overnight renders the virus unable to infect us. They will continue to protect others as long as we wear them. Respect.

What are you prepared to do today?

        Dr. Chet

Reference: https://doi.org/10.1016/j.matt.2020.10.006

COVID on a Plane

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We’re never very far from being reminded about the COVID-19 virus; there’s more info every day. This week, I’ll review three recent scientific papers about the virus. Because I’ve recently flown on an airplane, let’s begin there.

We would logically think that when you have upwards of 150 people crammed into a box that the risk of transmission is going to be high if someone is carrying the virus. My observation, at least on the flights that I was on, is that the airlines try to keep people socially distant, at least as much as possible given the limited space.

One of the things that assist in reducing the risk of transmission is the way that air flows through a plane. The air comes in near the top of the cabin and then circulates down and out at the base of the cabin. Half the air comes from outside the plane while the remainder of the air is circulated through HEPA filters, similar to those found in operating rooms. The risk of viral transmission on an airplane is lower than in office buildings, supermarkets, schools, and commuter trains.

Based on current estimates, there have been only 42 cases of traceable COVID-19 infections from flying. Worldwide! While there are no guarantees, as long as we follow the recommendations of wearing a mask, not traveling while we’re sick, and washing our hands frequently, it appears that it’s a safe way to travel if we really need to fly somewhere.

Just a reminder that there’s an Insider conference call this Wednesday night at 9:00 p.m. ET. On this month’s call, I’m going to introduce a new feature that will be coming to the Insiders subscription portal.

What are you prepared to do today?

        Dr. Chet

Reference: JAMA. 2020. doi:10.1001/jama.2020.19108

The Bottom Line on Cats and Dogs and Supplements

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One of my all-time favorite movie lines is by Bill Murray’s character in the original Ghostbusters. He goes on a rant about the coming plague of ghosts and says “…dogs and cats living together…” It’s the delivery more than the words, but it still makes me laugh. I often blurt it out when people talk about all the things that could go wrong if X happens.

I decided to search the literature for specific supplements that can benefit cats and dogs, whether they live together or not. There’s no research on multivitamins-multiminerals per se, although there’s some info on the use of vitamins and minerals as additives to food.

Cats and Supplements

There are two primary areas of research on supplements in cats. The first is the amino acid taurine and the other is joint issues. The lack of taurine in a cat’s diet can result in compromised immune systems, eye problems including blindness, deafness, cardiomyopathy and heart failure, and reproductive issues. Researchers have found that taurine supplementation can increase the taurine level in a cat’s cardiac tissue. One more thing: soy interferes with taurine absorption or utilization, so make sure that the food you feed your cat is soy-free.

The other issue is joint problems such as arthritis. In research on cats, the same blends used in humans that consist of glucosamine, chondroitin, Boswellia, and fish oil help alleviate pain as assessed by owner and veterinarian pain evaluations.

Dogs and Supplements

The big issue with dogs is joint problems such as osteoarthritis. Research shows that the same nutrients recommended for cats and humans are appropriate for dogs: glucosamine, chondroitin, Boswellia, and fish oil. When it comes to amino acids, dogs require 10 essential amino acids to be healthy. While they can get that from vegetarian protein, research shows that dogs can smell it when meals don’t contain all the essential amino acids and will avoid them. That’s some sniffer dogs have!

In the category of interesting research, the amino acid l-arginine together with antioxidants has been shown to benefit dogs with memory issues. Also medium-chain triglycerides are being tested in epileptic dogs to see if the supplement can help reduce seizures. Maybe a teaspoon of coconut oil every day can benefit these dogs—there’s no harm in it while waiting for the research to be completed.

The Bottom Line

We love our cats and dogs and want them to being as healthy as they can be. Targeted supplementation for specific issues is certainly warranted, and it’s probably good to use the same recommendations for us humans and for our best friends: eat better, eat less, and move more. You’ll both be healthier for it!

What are you prepared to do today?

        Dr. Chet

References:
1. Vet Med Sci. 2019 Aug;5(3):325-335. doi: 10.1002/vms3.1822.
2. J Nutr. 1995 Nov;125(11):2831-7. doi: 10.1093/jn/125.11.2831.
3. Am J Vet Res. 1992 Feb;53(2):237-41.

Do Cats Need Vitamins?

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Absolutely no way I could write about dogs without talking about cats as well, and there’s good reason: my daughter-in-law is an ardent cat advocate. She and our son act as foster parents for kittens from their local animal society until they’re ready for adoption so that when they join a family, they’re accustomed to being around people. When you have grandcats, even only for a few weeks, you want to see how they’re doing and what Matthew and Kerri have named the latest pair. I also want to see that they do well, so the topic was relevant: can cats take vitamins and minerals?

When the National Academy of Sciences put together the report on dogs, they also did the same type of brochure for cats, and again the quantities seem proportional to body weight.

One difference I noticed about cats is that they require the amino acid taurine to be healthy. As a result, while dogs could do well on a vegetarian diet with enough protein, cats require animal protein. You can check out the entire PDF to get additional information.

What are you prepared to do today?

        Dr. Chet

Reference: www.nap.edu/resource/10668/cat_nutrition_final.pdf

Do Dogs Need Vitamins?

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I recently got a question from a long-time listener who asked if it was okay to give the dog a partial serving of their multivitamin-multimineral. I didn’t have a clue—I don’t deal with supplements and animals, with the exception of glucosamine and fish oil. Both are good for dogs, but what about the rest of the supplements?

One supplement I know they don’t need is vitamin C, because dogs can make their own vitamin C. In fact, only humans and one variety of bat can’t make their own vitamin C; all other mammals can. While too much C can be hazardous, the amounts found in most multis for humans should be fine for dogs. But what about the rest of the vitamins and the minerals?

Wouldn’t you know that the same organization, the National Academy of Sciences, that establishes the Dietary Reference Intake for humans has done the same for dogs. In examining the list, they’re in proportion for what humans would take, but proportional based on body weight. The document also goes through the entire nutrition lifecycle of a dog. If you have a dog or dogs, just download this PDF.

And before you ask, we’ll talk about cats on Thursday.

What are you prepared to do today?

        Dr. Chet

Reference: www.nap.edu/resource/10668/dog_nutrition_final_fix.pdf

The Skin Microbiome: Skincare and Cosmetics

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While the state of the current pandemic has restricted the ability to socialize to any great degree, it may turn out to be beneficial for the skin microbiome. Be honest. If you don’t have to go to work or out into the public, do you still maintain the same personal grooming practices? Do you put on all your makeup? Based on what people say in virtual meetings, the answer is no. Why is that beneficial for the skin microbiome?

The final potential insult to our skin microbiome is from products we willingly use. Most people apply some form of skincare and/or cosmetic products every day, plus deodorant or anti-perspirant, haircare products, moisturizers, and a plethora of make-up products. Here’s the key point: most of these products contain anti-microbials to maintain the safety of the product before use. That means when applied to the skin, they could also impact the microbiome of the skin.

After reading a review article on the state of research on the entire gamut of skincare products, several researchers outlined the type of research that should be done. While encouraging, that means that not much has been done. I couldn’t find any research that directly examined the impact of skin and cosmetic products on the skin microbiome. We just don’t know.

Strategies for Healthy Skin

There are several things we can do to indirectly help our skin.

  • Drink one-half your body weight in ounces of liquid every day.
  • Take 1 to 4 grams of omega-3 fatty acids every day. There are many reasons to take your omegas, but one is to help reduce the production of inflammatory hormones.
  • Take a probiotic with several types of bacteria with a prebiotic every day. They contribute to a healthy immune system and internal microbiome.
  • There are several supplements that may also contribute to the health of the skin including biotin, vitamin C, and collagen. They may not affect the skin’s microbiome, but starting with a healthier surface may be beneficial.
  • Regular exercise increases blood flow to all areas of the body, including the skin. That can deliver nutrients and help remove waste products.

The Bottom Line

Our skin microbiome is part of our first line of defense against microbial invaders. At this point, there’s not enough research to know whether the skincare routines we’ve become accustomed to are beneficial, harmful, or at least neutral. Is that worth stopping all skincare and cosmetic products? Should we stop taking showers? I don’t think we need to do any of those, but if we start paying more attention to the products we use and make better choices in selecting them, that may give us an edge while science catches up with this amazing part of our immune system.

What are you prepared to do today?

        Dr. Chet

Reference: Int J Cosmet Sci. 2020 Apr;42(2):116-126. doi: 10.1111/ics.12594.

The Skin Microbiome: pH

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The water we shower and bathe in may impact our skin microbiome, but we don’t generally just rinse off with water. We use soaps and shampoos as well. How could they impact the microbiome of the skin? Let’s take a look.

Normal healthy skin has a pH range of 5.4 to 5.9. At that pH, the body maintains a normal microbiome. Researchers examined the pH of shampoos and soaps in about 100 different products. Most soaps were highly alkaline with a pH that averaged between 9 and 10. Shampoos fared much better with most in the 6 to 7 pH range.

Will the exposure to these products damage the skin microbiome? If it does, will it be temporary? After all, the exposure will be limited depending on the length of the shower or bath. We don’t have all the answers on that. The closest I’ve seen to sequential testing was a multi-country study that found that the skin pH was still elevated six hours after washing with soap. The rise was less than a single point; still, the actual impact on the microbiome wasn’t evaluated. There’s still much we don’t know.

We’re still not done with the skin microbiome so we’ll finish this up on Saturday.

What are you prepared to do today?

        Dr. Chet

References:
1. Int Microbiol. 2019 Mar;22(1):1-6. doi: 10.1007/s10123-018-00049-x.
2. Indian J Dermatol. 2014 Sep-Oct; 59(5): 442–444. doi: 10.4103/0019-5154.139861.
3. International J of cosmetic science. 2006 DOI: 10.1111/j.1467-2494.2006.00344

The Skin Microbiome: Birth and Water

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I began last week’s focus on the skin microbiome based on reading an interview with a scientist who hasn’t taken a shower in over five years (Clean by James Hamblin). We’ve established the basics about skin and the microbes that are supposed to reside in the skin microbiome. This week we’ll cover how the skin microbiome is affected by our environment. What are we doing to our skin that may be impacting our health?

It actually can begin at birth. If we are delivered via the birth canal, we are immersed in vaginal microbes that seed our skin with microbes. In the 1970s, C-sections began to rise from 5% to the current rate of 30%. That means close to one-third of newborns don’t get the initial exposure to skin microbes. Does that result in an increase in skin conditions such as dermatitis? Maybe, but there’s no confirming research to date.

Depending on your water supply, the water may be treated with chlorine and fluoride. While they can kill bacteria to make the water safer, those chemicals may also damage the microbes that live on our skin, hence Hamblin’s avoidance of showers. That impacts the skin microbiome and consequently, our immune system.

What else can impact our skin? I’ll cover more on Thursday.

What are you prepared to do today?

        Dr. Chet

Reference: Int Microbiol. 2019 Mar;22(1):1-6. doi: 10.1007/s10123-018-00049-x.