Is Protein Bad? The Research

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Let’s think about this logically. If we wanted to prove that a high-protein diet would decrease lifespan, we would have to feed some type of animal a diet high in protein until all the animals had died. It would be preferable to have animals that don’t live very long such as rodents. Then we compare the lifespans and causes of death with a control group. Simple and straightforward.

That’s not what the research group did. As I said in Tuesday’s Memo, they identified an enzyme called eukaryotic elongation factor 2 kinase (eEF2K) that slows the rate of protein synthesis. That enzyme is also found in C. elegans, a nematode, as well as in fruit flies and humans. They knocked out the eEf2K enzyme, therefore causing protein synthesis to happen faster. This is supposed to be what happens when too much protein is eaten. They noted more mistakes in protein synthesis as a result.

The methodology for this series of experiments is beyond my expertise. By a lot. Whether the research was on cancer cell lines, the nematodes, or the fruit flies, what I could not find in the Methods section is where they added protein or amino acids to the food for any culture or animal to mimic a high-protein diet. I wrote to the study’s lead author to see if my analysis was correct, but I haven’t gotten a response yet.

What does all this mean? I’ll wrap it up on Saturday.

What are you prepared to do today?

        Dr. Chet

Reference: Cell Biology 2019. https://doi.org/10.1016/j.cub.2019.01.029/

Does Protein Decrease Lifespan?

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Just when we’ve accepted that carbohydrates are bad for us and everyone seems to be doing the paleo or ketogenic diets, a new study from an Australian research group created headlines by suggesting that high-protein diets are unhealthy because they decrease longevity.

For years we’ve been told that high-fat diets are bad. Then scientists suggested that it’s carbohydrates that are bad, which led to this keto-everything dietary phase we’re in right now. Now we’re being told that high-protein diets are bad for us as well? What the heck are we supposed to eat? Before we panic, let’s take a look at the research to see if it’s meaningful or not.

Researchers identified an enzyme called eukaryotic elongation factor 2 kinase (eEF2K) that slows the rate of protein synthesis. By so doing, it reduces the number of mistakes made in making or folding proteins. If a long-chain protein such as insulin has mistakes in the location of amino acids, the protein will not work as it should. When you consider the number of proteins the body has to make to function every second, too many mistakes could lead to disease and thus reduce our lifespan.

Is this real? Let’s take a look at how the research was conducted to figure out whether we have to be concerned or not.

What are you prepared to do today?

        Dr. Chet

Reference: Cell Biology 2019. https://doi.org/10.1016/j.cub.2019.01.029/

Fasting: A Metabolic Do-Over

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The changes that occur during fasting are remarkable. Blood sugar is maintained within normal ranges. Protein and other breakdown products can be used to make glucose. And there’s one more significant finding: levels of purines and pyrimidines increased during the fast. These are some of the substrates for making proteins and nucleic acids used for making DNA.

What does that mean? Fasting isn’t just a one-way event where things are only broken down; some are being rebuilt. Prior research on cancer patients have shown that a 48–96 hour fast helps use up immune system remnants and rebuilds the immune system. In those cases, they were reduced to 500–800 calories under hospital conditions. The fast helped them do better during chemotherapy.

Before we get carried away, a couple of things. The study I reviewed had only four subjects, they were normal weight, and they were all 29–30 years old. We don’t know how this type of fast would impact an overweight 55-year-old with type 2 diabetes. There may be differences in which metabolites result, and the rebuilding process may be different. Still, it’s encouraging.

I felt fine throughout my fast, but I had a head start, albeit a forced one. I can’t say that I notice any major differences except for the eight-pound difference in the scale. But how can you say that you feel your immune system is stronger or that your DNA is being replicated with fewer errors? You can’t.

This was not the type of fasting that manipulates the schedule so people can eat within a four-hour window and “fast” the rest of the day. I know people feel better and may lose weight, but there’s no evidence of any metabolic changes as significant as these. What is being attempted is to fit the fast into our lifestyle instead of letting it go organically for a day or two, and the benefits are important even if they’re not as dramatic as those in the study. Another name for this type of fast: a cleanse. What I think it proves is that you don’t need anything other than the will to do it for you to see some benefits. You don’t even have to abstain from food. You just have to do it.

If you want some guidance on doing a fast/cleanse, get out your copy of Real-Life Detox and get going. If you don’t have one, get your copy today. It’s time for a metabolic do-over! What are you prepared to do today?

        Dr. Chet

Reference: https://doi.org/10.1038/s41598-018-36674-9

Gluconeogenesis: Making Sugar

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On Tuesday, I said that blood sugars remained stable in all subjects throughout the study. How can that be when they would most likely use all their stored sugar in 24 hours or so? Their bodies made glucose out of protein and scraps from the breakdown of other substances.

Many hormones and connective tissue are made out of protein and are typically repaired after damage. The liver can use some amino acids from the damaged proteins to make metabolites that can enter the citric-acid cycle. When those remnants become scarce, the Number One source is muscle. Skeletal muscle is our protein storage facility, and while it isn’t preferred to use protein in this way, the body is protective of your blood sugar level and will protect it no matter what; it will make sugar for energy using whatever is available.

Use of fat as a fuel also increases, primarily in the mitochondria. While it’s complicated biochemistry, mitochondria are then stimulated to become more active and produce more free radicals. The good news is that researchers also observed an increase in antioxidant activity. Glutathione levels remained constant but an analog of glutathione called ophthalmic acid increased, keeping the rise in free radicals in check.

There was one more significant set of metabolites that were released. I’ll cover that on Saturday. What are you prepared to do today?

        Dr. Chet

Reference: https://doi.org/10.1038/s41598-018-36674-9

A Case for Fasting

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During the food poisoning episode last week, I didn’t eat for 30 hours. Of course, I had slept most of that time and eating was the last thing I wanted to do. Even though I could have started eating again, I decided to continue the fast to at least 60 hours. I continued to drink fluids—I’m not going to live without coffee—but no food or drinks with calories.

Why do this? I had just scanned a research paper written by a Japanese research group who had four volunteers fast for that long. They observed interesting changes in metabolism by measuring by-products of metabolism in blood. They took blood samples before the study and then at 10 hours, 34 hours, and 58 hours. In prior research, they had discovered 14 changes in metabolites, but this time there were 30 more changes that occurred during the 58-hour fast.

It’s difficult to establish a time-course of events as they didn’t collect blood every two or four hours, but we can compare baseline numbers with the results of the other times blood was collected and analyzed. Initially the body relies on stored sugar in the form of glycogen, but eventually sugar gets used up and the body has to rely on fat stores. Here’s observation Number One: blood sugar was consistently maintained varying only 10 mg/dl over the observed times. Surprised? I’ll tell you why that happened on Thursday.

What are you prepared to do today?

        Dr. Chet

Report Food Poisoning

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What should you do if you get food poisoning? Report it. The procedure may vary state to state, county to county, and even city to city, but here’s what we did.

The first thing: Paula called the restaurant where we ate and told the manager what happened, what we ate, and when. We can’t be sure their food was the culprit, but that’s the only time Paula and I ate the same things for the prior 24 hours. What we had to eat before then we shared with Riley, and he never had any digestive issues. It doesn’t have to be an accusatory conversation, but they should know—think of all the people that may have eaten at the same place. The manager was grateful for the information and said she’d check their stock of the food we ate.

Then I looked up the procedures for the county. They had an online form to fill out that asked about the symptoms, the timing in relation to meals, and what we’ve eaten over the past 72 hours. I filled it out on Sunday and they called Monday to check on some details. The forms were very detailed, and that’s probably why most food poisoning isn’t reported. By the time we feel better, which is just usually a couple of days, we think it won’t make any difference. But remember that no one can count the incidences if we don’t report it and let the health department do its job. Every time we see on the news that romaine lettuce or whatever has been recalled, that’s all the health departments working together to do their jobs—but they can’t help us if we don’t help them.

Paula and I have recovered from our bout with food poisoning. It was a very unpleasant 48 hours, but we made it; Paula adds that vomiting hard every 60 to 90 minutes is a great core workout. Most cases of food poisoning are not going to be fatal; only 450 deaths were reported per year out of the 1.2 million reported cases of salmonella poisoning. We don’t know how many could have been prevented with better info from the public.

We can never be sure our food supply and our home cooking techniques are perfect, but we can strive to make them better. So if you suspect you’ve gotten food poisoning, tell your doctor, your health department, and the store or restaurant as soon as possible. It’s the right thing to do, and it could save many other people from a miserable day or two. It might even save a life.

What are you prepared to do today?

        Dr. Chet

The Most Likely Culprit: Salmonella

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Food poisoning happens more often than we think it does. Most often, we throw up once or have a single bout of diarrhea with no fever and no fatigue and it’s over. The question is how we know which type of bacteria was at fault. There’s no way to know for certain unless stool samples are tested, and that only happens if the case is severe enough that a person requires hospitalization. While I can’t be certain, my best guess is that Paula and I encountered salmonella, the most common form of food poisoning.

I base that on the length of time from the onset of symptoms and the type of symptoms. Salmonella may or may not cause a fever, but it can cause vomiting and diarrhea. The Centers for Disease Control estimate that 1.2 million people get salmonella infections per year but as I suggested, it could be much higher; only 23,000 people per year are hospitalized with food poisoning. Most people get over salmonella within a few days with no lasting effects.

How do you know when to seek medical assistance? When the symptoms are very severe and last longer than is reasonable: 36–48 hours would be my guess. An inability to keep anything down or severe diarrhea can cause dehydration and that’s definitely not good. Children under five and people over 65 are the most at risk for hospitalizations because their immune systems are most likely to be compromised and dehydration is a greater risk.

What should you do if you suspect food poisoning? I’ll let you know on Saturday.

What are you prepared to do today?

        Dr. Chet

Is It Food Poisoning?

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It all began Saturday evening. Paula and I had gone out to dinner to celebrate the 31st anniversary of our first date and were watching a little television. After finishing a show, she said she felt like throwing up. She decided to get ready for bed while I channel flipped for awhile. I found out later she had thrown up almost hourly all night long. It continued all the way through most of the next day. The vomiting skipped me, but I had diarrhea the rest of the night and throughout the next day. Neither of us had a fever, but the symptoms continued. I’ve never slept so much in 24 hours ever.

As I write this, we both feel better. I still feel 10 cents short of a dollar, but that raises a more important set of questions. What is the most likely culprit? What should you do if you get these symptoms? More important, what should we do to let others know? I didn’t choose this topic—it chose me—but that’s going to be the focus of this week’s Memos.

Tomorrow night is the Insiders Conference Call. The primary topic is probiotics and then I’ll answer your questions. You can still participate by becoming an Insider today.

What are you prepared to do today?

        Dr. Chet

Vaping: Better Than Tobacco

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Today’s final look at vaping and quitting smoking considers the following question: Does the use of vaping to quit smoking result in eliminating the dependence on nicotine? Based on the research, the answer is no, because there’s no research that attempts to answer that question that I could find. Knowing the powerful addictive qualities of nicotine, the only assumption we can make is that vaping does not result in breaking away from nicotine. Therefore when it comes to that question, vaping transfers the nicotine addiction from one delivery system, tobacco, to another delivery system, electronic nicotine-delivery devices. The addiction remains.

But we can still say vaping is better than smoking or chewing tobacco simply for the reduction in chemical exposure.

Maybe the assumption is that nicotine is benign. It isn’t. It has powerful effects on the cardiovascular and nervous systems as well as the adrenal and pancreatic glands. But that isn’t the only issue.

Research Questions

Besides the long-term effects of vaping on the body as well as the question I posed above, there are still several questions that have to be answered.

  • What is the effect of the incineration of the flavors used in vaping juices? The assumption is that because they come from fruit and other juices, they’re natural and won’t have any negative effect on the teeth, the trachea, and the lungs. We know that cooking changes the chemicals in the fruits and vegetables we eat; we also know that when eaten, they have no negative impact on the digestive system, but there’s concern that some of the by-products may be harmful to the lungs. We have no idea what incineration of the juices at high temperature will create. Remember that tobacco is a plant, too—it’s not that different.
  • What is the effect of the smoke or vapors on other people? Vaping generates second-hand smoke just as smoking does, but there’s no research on that.
  • Will childhood vaping lead to nicotine experimentation and addiction? Vaping devices have been marketed like candy to children for their taste. Nicotine cannot be advertised to children, hence the warning in the television ad that began this series, but the concern is that once using the same type of e-cigarette delivery system with fruit juices, it will be a small step for the kids to try the nicotine forms when they’re old enough, if not before.

The Bottom Line

At this time, vaping is better than smoking or chewing tobacco due to the reduction in exposure to toxic chemicals. However, it’s not correct to suggest that vaping is safe until the above research has been done. Until research demonstrates that vaping will lead to helping smokers break their addiction to nicotine, it’s the best route available to help people quit smoking and probably to quit chewing tobacco, although that’s not been tested. But that still doesn’t make it healthy.

If you want to know more about nicotine, the business of vaping and my personal experience with cigarette smoking become a Member or Insider at drchet.com. I cover those issues in the latest episode of Straight Talk on Health.

What are you prepared to do today?

        Dr. Chet

Reference: Ther Adv Respir Dis. 2018 .doi: 10.1177/1753465817744960.

Do Vapes Help People Quit Smoking?

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The only answer at this point is maybe. In the most recent review of the literature, population-based studies that rely on surveys and questionnaires suggest that vaping helps; the problem is that while they tells us something about the population as a whole, it tells us nothing about an individual. We’re still missing randomized placebo-controlled trials. The placebos wouldn’t have to have zero nicotine but should have a variety of doses to assess the best dose of nicotine for quitting; after all, nicotine patches and nicotine gum have been available for decades and have proven to be only 7% effective over a year.

The premise of vaping is that it’s healthier than smoking cigarettes. Is it? When you consider the hundreds if not thousands of chemicals released from tobacco cigarettes, the answer would be yes. Switching from cigarettes to vapes is better from that perspective. But does vaping really help people quit smoking?

One of the characteristics of recent electronic nicotine-delivery systems is the use of liquids with higher doses of nicotine, close to what is found in cigarettes. It may take these higher doses to help people quit smoking.

What are you prepared to do today?

After they quit smoking cigarettes, how long does it last? Research from the United Kingdom suggests that vaping help smokers quit with the use of traditional quit-smoking programs. The long-term effectiveness remains unknown. Which raises the second question: are people able to get off nicotine altogether? I’ll talk about that on Saturday.

        Dr. Chet

References:

1. Ther Adv Respir Dis. 2018 .doi: 10.1177/1753465817744960.
2. Cochrane Database Syst Rev. 2016. doi: 10.1002/14651858.CD010216.pub3.