Hold on to Hope

Basic science research is critical to finding cures for degenerative conditions and diseases; a recently published study illustrates how that happens. Researchers identified a cell receptor that regulated muscle and bone cell metabolism called GRP133 about 15 years ago. Recent research has shown that a protein called AP503 can be a receptor agonist for GRP133, necessary to activate the production of bone and muscle-cell production. Recent research in mice has shown that it can reverse osteoporosis and sarcopenia in mice. (If you’re thinking that this sounds like the GLP-1 agonists for diabetes and weight loss, you’d be correct.)

This may prove to be a whole or partial solution for osteoporosis—in about 10 or 15 years, that is. There’s a lot of testing that has to happen before it’s ready for human use. The key is to make sure that there are no other side effects of taking AP503, which could cause more serious problems than it solves. But for now, it provides hope.

One of the feelings this time of year brings is hope. No matter what your health issues are, from the inconvenient—such as going bald—or a serious disorder, we hope there will be a solution, partial or complete, as basic science continues and leads to new ways of treatment. Since the completion of the genome projects decades ago, I’ve believed that.

The key is to do everything you can do today to live long enough to see the science come to fruition with the solution.  There is hope.

What are you prepared to do today?

        Dr. Chet

Reference: Signal Trans Target Ther. 2025 Jun 30;10:199. doi: 10.1038/s41392-025-02291-y