Tag Archive for: allergic rhinitis

Research Update on Probiotics and Adult Allergies

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Researchers recruited a total of 95 adults, ages 19 to 65, with allergic rhinitis for a double blind, randomized, placebo-controlled clinical trial; all the subjects were from two hospitals in South Korea. They were not allowed to take their usual medication to treat seasonal allergies.

In the experimental group, 47 subjects received the probiotics, and 48 subjects were in the placebo group. The probiotics used in the study was a novel blend called NVP-1703. The variables the researchers selected to track were markers associated with the immune response such as IgE and interleukins. They also tracked the symptoms of the subjects by having them complete daily diaries noting responses such as sneezing, itching, nasal congestion, runny nose, etc. The subjects also took standardized written allergy questionnaires.

The researchers found significant positive changes in the questionnaire assessment from baseline through weeks one, three, and four between the probiotic group and the placebo group. The IgE levels and serum IL-10 levels were significantly improved between the probiotic and the placebo group.

The improvement in questionnaire results meant that the subjects that were taking the probiotics saw their allergy symptoms decrease. By assessing the immune responses, they saw that somehow the probiotics stimulated the production of IgE and IL-10. Both of those allow the immune system to control symptoms associated with allergic rhinitis.

The researchers concluded that this blend of probiotics could be beneficial to treat seasonal allergies; I’m not sure I would go that far since the study contained fewer than 100 subjects. I would say that it was nice progress, although there’s still more to do. But if you have allergies, taking your probiotics regularly may be helpful for your allergy symptoms as well as all the other benefits.

What are you prepared to do today?

        Dr. Chet

Reference: Nutrients 2020. 12: 1427-41.; doi:10.3390/nu1205142

Research Update on Probiotics for Infants

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Let’s begin this week’s research review with a study on the potential long-term benefits of probiotic use in infants. Researchers in Slovenia collected data on 316 healthy-weight newborns whose parents had test-confirmed allergies.

The families were divided into two groups: 115 infants were placed into a probiotic group and received probiotics every day between the ages of four weeks to twelve weeks while breastfeeding. The remaining 201 infants were put in the control group and breastfed without any supplements.

All children were followed by the same pediatrician through nine years of age to assess the children over the years to see who developed allergic rhinitis or allergic rhino conjunctivitis at some point. The results showed during the follow-up that 19.6% of the children had developed either form of allergy. They confirmed the diagnosis by examining the children for levels of IgE and skin prick tests.

Children in the probiotic group were three times less likely to develop allergic rhinitis than those in the control group, 4.3% versus 13.9%. When examining allergic rhinoconjunctivitis, the difference between the probiotic group and the control group was much lower although still statistically significant at 8.7% versus 9.5%.

I like this study because the children were tracked for an extended period of time. It may be that if the infants were tracked only through one year of age or if the study were terminated when they were four or five, there might not have been the same significant differences. Sometimes seeing the benefits can take longer than we expect.

You have to wonder what the results would be if the children were given probiotics beyond twelve weeks (some may have been; probiotics weren’t prohibited beyond the study.) We make sure Riley, who’s five, gets his probiotics every day.

Is that reduction in allergies worth the effort? Paula says any lessening of allergies is worth doing. Next month will be the 57th anniversary of her first allergy shots, and she’s been getting shots nearly continuously ever since—three at a time these days. If probiotics will spare some children years of shots or medications, let’s go for it.

What are you prepared to do today?

        Dr. Chet

Reference: EAACI Digital Congress 2020. Besednjak-Kocijančič, L. et al.