Tag Archive for: amino acid

Brain Boon, Not Brainrot

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Maybe you’ve been hearing about brainrot; if you have a kid in the house, the odds go way up. My point in mentioning this is to suggest that peanuts don’t contribute to brainrot, but may be a brain boon as I talked about on Tuesday. The question was why?

Nutrients May Hold the Key

Peanuts, as well as other nuts, are high in the amino acid l-arginine. Nitric oxide (NO) increases dilation in blood vessels which help blood flow everywhere but especially to the heart and the brain. We usually associate nitrates from vegetables with that process, but there’s another pathway which uses arginine to increase NO levels as well. That could explain the increases in blood flow to the areas of the brain. The increase in NO could also partially explain the reduction in systolic blood pressure.

In addition, the fiber in peanuts, the antioxidant properties found in the peanut skin phytonutrients, and replacing saturated fats with unsaturated fats may also have an impact on blood flow. The peanut skins contain resveratrol, a phytonutrient that has shown promise in reducing cardiovascular disease in general.

Carbohydrate intake increased while fat decreased during the eating-peanuts phase of the study. One of the key findings was that the unsaturated fats in the nuts replaced some of the saturated fats in the diet. Overall, the peanuts were beneficial.

Limitations with Hope

This was a small study with essentially healthy older adults; how that might work for people with disease must still be tested. The cost of the methodology using special MRI analytics limited how many subjects would be realistic to study, but there were at least some benefits in every category they tested. This shows that modifying the diet in just one area may be a step toward improving your health. There’s no reason not to try eating peanuts (unsalted or lightly salted is preferable) to see how it impacts us personally.

What are you prepared to do today?

        Dr. Chet

Reference: https://doi.org/10.1016/j.clnu.2025.10.020

Cysteine for Gut Health

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The science behind the treatments of tomorrow lies with basic research today. There have been a couple of studies published recently that use building blocks of food to treat specific conditions. Let’s take a look at the first one today.

Researchers at MIT conducted a study to see if a specific amino acid could help the digestive system recover after damage due to radiation therapy for cancer. They tested 20 amino acids and found that cysteine stimulated the healing process in mice. They found that a high-cysteine diet increased the production of intestinal stem cells. While the actual biochemical process is very complex, it’s ready for human trials.

Why so quickly? Cysteine is a natural substance the body needs. Putting people on a high-cysteine diet for a time would provide no harm and may provide a boost to gut repair. In looking at the references, this approach is also being looked at for people with Crohn’s disease and irritable bowel syndrome.

How do you get a high-cysteine diet? Meat, dairy, legumes, and nuts are all high in cysteine, and it’s also available as a dietary supplement. If you have such issues, talk with your physician about giving the diet a try to see if it will help. Zeaxanthin is the next nutrient we’ll look at on Saturday.

Tomorrow night is the Insider Conference Call. I’m going to be answering Insider questions as well as discussing a couple of success stories for people who used GLP-1 RA to lose weight. Become an Insider by 8 p.m. tomorrow night and you can join us.

What are you prepared to do today?

        Dr. Chet

Reference: Nature (2025). https://doi.org/10.1038/s41586-025-09589-5

Is Taurine Safe?

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The title said, “Could your energy drink be fueling cancer?”

“Now what?!” was my first thought. Researchers reported in a press release that the amino acid taurine may help cancerous cells make energy to fuel their growth. Because taurine is found in energy drinks and protein supplements, I wanted to check whether this is something to be concerned about or not.

This was a complex study from the perspective of identifying what were the potential stimulators of tumor progression in bone marrow. A taurine carrier was identified. The researchers conducted tests which added taurine to specific types of leukemia cells to determine tumor progression. They concluded that further research was necessary to find something that would block taurine carriers from carrying taurine into tumor calls where they could stimulate the production of energy via glycolysis. That may be correct or not.

The methods section of the paper was over five single-spaced pages long; that doesn’t make it bad, but each unique test has to have a standard error of the method. In other words, how specific and precise does the method measure the variable?

  • Using available leukemia cell lines is a first step to test theories, but we don’t know if that’s how it would work in living human beings.
  • They did testing on rodents, but there were only a few rodents in each group.
  • On top of that, taurine is naturally produced in the body, and they specifically identified tumor sites as one of the locations where taurine is produced. How can that be differentiated from natural production and supplementation?

In my opinion, they were far too aggressive in their conclusions about energy drinks potentially fueling cancer. For now, the most conservative approach is that if you have an aggressive myeloid leukemia, consider reducing taurine intake from all sources, which would also include meats, dairy, and eggs. There’s a lot more research that has to be done before we definitively know how this information impacts the real world.

What are you prepared to do today?

        Dr. Chet

References:
1. https://scitechdaily.com/could-your-energy-drink-be-feeding-cancer-what-scientists-just-discovered/
2. Nature. https://doi.org/10.1038/s41586-025-09018-7

When Will We Get Something Better?

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The quest for a pharmacological solution to obesity continues—the magic pill to make us thin. While Ozempic and Wegovy, discovered and developed to treat type 2 diabetes, have been successful in helping reduce HbA1c, it has also helped people lose weight; the problem is the side effects. As you might guess, there are receptors for GLP-1 agonists in numerous locations in addition to the brain, and other organs are impacted.

That’s why a press release from Stanford seemed promising: “Naturally occurring molecule rivals Ozempic in weight loss, sidesteps side effects.” This research used a unique approach: they designed a specific algorithm that used artificial intelligence to identify the hormone segments made by an enzyme prohormone convertase 1/3 (PC1/3); basically, it cuts prohormones into smaller segments. Some may have metabolic activity, most would not.

Based on the analysis of 2,600 protein segments, the researchers identified 373 potentials and tested the top 100 most likely to succeed. They identified a hormone segment with 12 amino acids that appears to impact hunger 10 times better than the GLP-1 agonists, which are cleaved from the same prohormone. When they tested it in mice and minipigs by injecting it into the muscles of the animals before eating, it reduced food intake by 50%.

The volume of work done by the specific algorithm using AI probably saved years compared to testing each prohormone by trial and error, but what’s next? When will it be available? I’ll cover that on Saturday.

What are you prepared to do today?

        Dr. Chet

References:
1. https://med.stanford.edu/news/all-news/2025/03/ozempic-rival.html
2. Nature (2025). https://doi.org/10.1038/s41586-025-08683-y

Should You Increase Your Protein Supplement?

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The research paper we’re reviewing demonstrated that there seemed to be a dose-like response to protein intake after intense exercise; that is, the more protein, the more muscle synthesis. And it lasted at least 12 hours instead of the prior four to six hours for a lower dose. Also, the excess protein intake wasn’t used to make energy to any great degree as previously thought; that means less strain on the kidneys, because when protein is broken into individual amino acids, the nitrogen group won’t have to be eliminated via the kidneys.

As always, there are more questions to be answered before this study becomes the new normal.

To Be Determined

The obvious issue is that the subjects were all young men from 18 to 40. Would the same results happen in women? And would the same result happen in older subjects, such as those in their 50s or 60s?

Next question: would the extra protein be absorbed and used the same way without the intense exercise session? The subjects did four different exercises using the legs and chest with four sets of ten reps, pushing the subjects to failure on the final three sets. Pushing yourself that hard can be challenging and even dangerous without help. Could someone with known cardiovascular disease push themselves as hard without causing a cardiovascular event? Would metabolic diseases such as type 2 diabetes impact how protein was utilized?

I could go on, but you get the point. One study with fewer than 40 young subjects, using testing procedures that will not be easy to duplicate, isn’t a basis for changing protein intake after exercise for everyone.

What Does It Mean?

The obvious answer is that it provides a new area of research. I would be most interested in how the use of essential amino acids could impact the protein synthesis in addition to additional protein intake. But let’s stick to what it means beyond future results.

On the days that you lift weights, even though perhaps not as intensely as the subjects in this study, add an additional 10 or 25 grams of protein to your post-workout shake. Milk protein was used as the source in this study, but other sources of protein powders would probably obtain the same result. The composition of protein powders doesn’t vary much, so choose whatever appeals to you.

The men began drinking their shake after they completed the exercise session. I recommend drinking extra water for a couple of hours after the shake. Do that for a specific number of weeks and see what happens. Track whether you’re able to increase weight or add muscle.

If you don’t do resistance exercise, you can see how you respond to the additional protein after a long walk or a yoga session. You might feel better with the additional protein.

The Bottom Line

Nutrition is a constantly changing field. Some basic assumptions that developed can now be reconsidered with better technology to test benefits or pitfalls. While it may take years or even decades before we have answers, what’s really important is how you respond. Adding some additional protein such as 10 or 25 grams to your morning or post-workout shake is not unreasonable to see how it benefits you. All the research in the world still comes down to how it affects you and your unique body; for example, certain antihistamines put some people to sleep and keep other people awake. As long as you’re reasonably healthy, you are your own subject.

Just remember: keep track of what you do and find a way to assess the outcome. After that, it comes down to one question: 

What are you prepared to do today?

        Dr. Chet

Reference: Cell Reports Medicine https://doi.org/10.1016/j.xcrm.2023.101324

Reconsidering Protein Supplement Amounts

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One of the basic tenets in sports nutrition is that we shouldn’t consume more than 25 grams of protein in a drink product. The reasoning has been that more won’t help you to add more muscle after a workout. This has trickled down to the point that it applies to anyone who drinks a protein shake. Based on a recent study, that may not necessarily be true.

First, let’s review why you want to build muscle. Obviously, more muscle helps you do more with your body: lift heavier objects or move your body more easily. Muscle is more dense than fat, so it takes up less space; when you are more muscular you look slimmer as well as more fit. Maybe most important, more muscle burns more calories; you can use that fact to lose weight or to eat more food.

Researchers wanted to test how long muscle synthesis would continue after an hour-long intense weight training session. The study was simple in design: take 36 young men who were physically active, test their initial exercise capacity, and then subject them to an hour-long weight training session in a laboratory setting. Afterward, in a randomized way, 12 of them got 100 grams of a protein drink, another 12 got 25 grams of the same protein drink, and the final 12 got a placebo that had no protein.

That’s where the simplicity stopped. The protein had specific quantities of carbon-labelled amino acids including leucine, the amino acid responsible for initiating protein building in muscle. The objective was to monitor whether protein synthesis lasted more than four to six hours, the previous conventional thinking. The other question is whether the excess protein would be used for making energy.

The short answer is that protein synthesis lasts at least 12 hours (and perhaps longer) at the highest intake, 100 grams. There is more to it than that, and I’ll cover it on Saturday.

What are you prepared to do today?

        Dr. Chet

Reference: Cell Reports Medicine https://doi.org/10.1016/j.xcrm.2023.101324

Gluconeogenesis: Making Sugar

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On Tuesday, I said that blood sugars remained stable in all subjects throughout the study. How can that be when they would most likely use all their stored sugar in 24 hours or so? Their bodies made glucose out of protein and scraps from the breakdown of other substances.

Many hormones and connective tissue are made out of protein and are typically repaired after damage. The liver can use some amino acids from the damaged proteins to make metabolites that can enter the citric-acid cycle. When those remnants become scarce, the Number One source is muscle. Skeletal muscle is our protein storage facility, and while it isn’t preferred to use protein in this way, the body is protective of your blood sugar level and will protect it no matter what; it will make sugar for energy using whatever is available.

Use of fat as a fuel also increases, primarily in the mitochondria. While it’s complicated biochemistry, mitochondria are then stimulated to become more active and produce more free radicals. The good news is that researchers also observed an increase in antioxidant activity. Glutathione levels remained constant but an analog of glutathione called ophthalmic acid increased, keeping the rise in free radicals in check.

There was one more significant set of metabolites that were released. I’ll cover that on Saturday. What are you prepared to do today?

        Dr. Chet

Reference: https://doi.org/10.1038/s41598-018-36674-9