Tag Archive for: cholecalciferol

My Verdict on D3 vs. D2: A Draw

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The medical community and the health gurus agree, and the research appears to agree with them: vitamin D3 is better than vitamin D2. A no-brainer, it would appear.

No. My call at this point: it’s a draw. Here’s why.

The Current Research

The research on vitamin D and absorption is a mess. There’s little to no consistency. You saw the number and attributes of subjects, quantity of the supplemental forms of vitamin D, and the length of the studies. The bulk of the studies use therapeutic doses, 50,000 IU and up, to see how the forms of D are absorbed to treat serious deficiencies of vitamin D in people. Vitamin D2 has been used for treatment for decades that way and still is today.

It’s true, that vitamin D3 does increase blood levels of vitamin D more and it seems to last longer than D2. So what? This is not a medication, it’s a nutrient. Why would anyone stop taking it? What the research proves is that levels of both forms of D decline after a person stops taking the supplement. I could have predicted that without doing a single study.

The study that came closest to reality that D3 is better than D2 was the study on hip fractures—at least that lasted three months. The studies that last longer give higher doses, up to 500,000 IU in a dose, and see what happens over a year. Why? What will that tell you? No one takes supplements like that.

The Ideal Study

If I could construct a study, I would track a large group of people divided into a placebo group, a group taking vitamin D3 only, a group taking vitamin D2 only, and a group given half the dose each of D3 and D2. It would also use off-the-shelf dietary supplements; when researchers have specific products formulated that are not for sale, the resulting info is worthless to us as consumers. The dose should be reasonable such as 2,000 or 5,000 IU. Subjects should be followed for at least a year. Several variables should be checked regularly.

The Bottom Line

Based on my assessment of the current research, vitamin D3 is better absorbed and converted to active vitamin D than D2, but there’s no evidence that D2 is not effective or that it’s harmful—it’s been used nearly 100 years! In my opinion, it may require a third more D2 to equal D3 to get equivalent effectiveness. Other than that, if you want the vitamin D you take to be effective, the only thing you need to do is take it consistently.

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What are you prepared to do today?

Dr. Chet

 

The Research on Vitamin D3 vs. D2

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One area that the medical field and the health gurus agree: vitamin D3 is better absorbed and utilized than vitamin D2. Four studies are constantly referenced when the best type of vitamin D is discussed (1-4); here’s a quick look at those studies.

Study 1: 4,000 IU vitamin D3 and D2 supplementation was given to 55 and 17 subjects respectively; the study lasted 14 days.

Study 2: 50,000 IU of each form of vitamin D was given to two groups of 10 men once; the men were followed for the next 28 days to monitor changes in vitamin D levels.

Study 3: 95 inpatients with hip fractures were randomly assigned to receive 1,000 IU of vitamin D3 or vitamin D2; the subjects were tracked for three months.

Study 4: 32 elderly women, split into groups of eight subjects, were given 300,000 IU of vitamin D3 or D2 orally or via muscular injection; they were monitored for the next 60 days.

The results from each study concluded that vitamin D3 was better than vitamin D2 at raising serum vitamin D levels. Is this the final conclusion that can be reached? Could there be questions that weren’t answered in these or any studies so far? I’ll let you know on Saturday.

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Dr. Chet

 

References:
1. Am J Clin Nutr. 1998 Oct;68(4):854-8.
2. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91.
3. Bone. 2009 Nov;45(5):870-5.
4. J Clin Endocrinol Metab. 2008. 93:3015-3020.

 

Vitamin D3 vs. Vitamin D2

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Many of you have questions about the different forms of vitamin D available in supplement form: vitamin D3, known as cholecalciferol, and vitamin D2, called ergocalciferol. Although they’re slightly structurally different, both have been used for years to help with vitamin D deficiency.

Vitamin D is necessary for bone health, of course, but research has found D to be related to other conditions such as depression, multiple sclerosis, and more. Vitamin D is a vitamin we can make ourselves when exposed to the correct ultraviolet radiation, but we shun the sun these days for a variety of reasons; both D2 and D3 are available in foods such as fish and dairy. Today getting a vitamin D blood test is commonplace; if it’s low, vitamin D will be prescribed by your physician, and of course you can buy vitamin D as a supplement.

Why the controversy about the form D3 or D2? Many Internet gurus and medical blogs from major health organizations claim that D3 is the only supplement you should use; D2 is not as good because it’s not as well absorbed and it can cost more.

What does the research say? What form should you take? We’ll find out this week as I review the research on both forms of vitamin D.

Remember, the Super Bowl Webinar is this Sunday. You don’t want to miss this one! All you have to lose is some fat.

What are you prepared to do today?

Dr. Chet