Tag Archive for: immune system

The Skin Microbes: What They Eat

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When we talk about the microbiome of the digestive system, it’s well-known what they eat: sugar. That’s also mostly true for the skin’s microbiome, although those microbes eat other substances as well. In today’s Memo, we’ll cover the types of bacteria and where they’re located. Then we’ll look at their diet.

The Microbes of the Skin

It may come as no surprise that the type of bacteria and other microbe depends on the location. That makes sense: what may grow well in moist areas may not grow well in dry areas.

The sebaceous sites on the head and torso are dominated by species of bacteria that like fatty environments. Remember that sebum is primarily a type of fat, so the type of bacteria that will grow in that area has to be able to thrive in that environment. The Propionibacterium species dominates in the oil glands.

The moist and humid sites contain bacteria such as Staphylococcus and Corynebacterium species. They thrive in the bends of the elbow and the feet, as well as other locations.

Bacteria are not the only important microbes in our microbiome; there are plenty of fungi as well, and I know how gross that may seem to some readers, but try to think about how much you like mushrooms. They’re there to do a job: protect us. The genus Malassezia are found at core body and arm sites. The feet are more diverse in fungi species: Malassezia, Aspergillus, Cryptococcus, Rhodotorula, Epicoccum species as well as others. Here’s something that may comfort some of you: bacteria were the most abundant and fungi were the least abundant.

What about viruses? They seem to be specific to the individual without any single virus dominating. Based on the longitudinal studies of the skin microbiome, they remain largely stable for as long as two years, the length of the longest studies. Pretty amazing considering how the seasons change in places like here in Michigan.

What the Skin Microbes Eat

The skin provides a cool and acidic environment for its residents. The primary nutrients are protein and fats. The microbes have adapted to what’s available in the sebaceous glands, the sweat, and the dead skin cells of the stratum corneum.

For example, the anaerobe P. acnes can survive and thrive by using protein enzymes to break down the amino acids found in the dead skin cells of the corneum stratum. Not only that, they have lipases to breakdown the triglycerides in sebum to use fat as a fuel as well as provide the means for the bacteria to adhere to the skin.

The lipids that can be liberated from the oily sebum and the stratum corneum are also used by the fungi for lipids as they cannot manufacture their own lipids. The Staphylococcus spp. have developed several strategies to survive the dry areas of the body. They’re tolerant of the high salt content of the skin and can use the nitrogen group from urea as a nitrogen source. They also produce chemicals that can break down the stratum corneum to extract nutrients from there as well.

As the researchers who wrote the review paper said, “the skin harbors a heterogeneous community of microorganisms that each have distinct adaptations to survive on the skin.”

The Bottom Line

As you can tell from this week’s memos, the skin microbiome is not just a few bacteria that decided to take up residence and are along for the ride; they have adapted to their environment to survive. How are they impacted by the water we bathe in, the soap we use, and the chemicals we use to look and smell better? That’s what I’ll write about next week.

What are you prepared to do today?

        Dr. Chet

Reference: Nature Reviews doi:10.1038/nrmicro.2017.157

The Skin Microbiome: Anatomy

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The skin microbiome is amazingly complex. Not only do we have all the beneficial bacteria and other microbes, we also have microbes that can be beneficial or damaging depending on how we treat the skin. Let’s begin with location: where are all these microbes located? For that, we need to understand a little bit about the structure of the skin.

The skin is the largest organ of the body and is constructed of two different layers: the outermost or the epidermis and an inner layer called the dermis. The outermost layer called the stratum corneum is composed of dead cells that are chemically crosslinked with each other and with cells below to provide a true barrier. As they’re sloughed off, they’re replaced.

To say “skin is skin” does this organ a disservice. It varies in different locations in the body and provides amazing microenvironments based on UV light exposure, pH, temperature, moisture, and sebum content. What is sebum? That’s the product of sebaceous or oil-producing glands, primarily located on the face, the chest, and the back. The sebum provides a coating that repels water and provides an antibacterial shield to hair and skin.

There are also areas of the body that are moist such as under the arms, between the toes, and in other more private areas. Those areas contain sweat glands which modify the pH of the skin and make it more acidic. That created an unfavorable environment for the growth of some bacteria and other organisms.

That’s the anatomy of the skin. The next question is what type of bacteria and other microbes are found on the skin and exactly what do they eat? We’ll cover that on Saturday.

What are you prepared to do today?

        Dr. Chet

Reference: Nature Reviews doi:10.1038/nrmicro.2017.157

No More Showers!

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If you saw a book called Clean, you probably wouldn’t think the author decided not to take any more showers. But you would be wrong, because that’s exactly what Dr. James Hamblin announced he would do about five years ago in a magazine article. Over time and a whole lot of research, the article became the basis for his book. In an interview I read with the author, he’s constantly irritated because the most frequent question he gets when people find out he hasn’t taken a shower in five years is “Do you stink?” My thought is if that you’re close enough to ask the question, you probably should know the answer, even with social distancing.

His primary concern over taking showers is our addiction to cleanliness, which is something I’ve thought about as well. (Never fear, I’m not going to quit taking showers.) His concern is with the microbiome of the skin. We all hear research on the microbiome within the digestive system just about every day, but the microbiome of our skin is actually the first line of defense in our immune system. Whatever we do to our skin affects the microbiome of our skin. With all the various soaps, detergents, and shampoos, as well as the chlorine that’s in most water treatment systems, that has to have some impact. Is the impact good or bad?

That’s what we’re going to take a look at in this week’s memos. Could how we treat our skin microbiome impact our immune system? We’ll look at the state of research to date.

What are you prepared to do today?

        Dr. Chet

Reference: Clean The New Science of Skin. James Hamblin. Penguin Random House. 2020.

Exercise vs. Meditation? The Winner Is…

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As a trained exercise physiologist, if I were asked the question, “Which would prevent acute respiratory tract infections?” I would have picked exercise over meditation every time. The only reason I would choose meditation is that nagging voice in the back of my brain that says, “If they’re asking the question, maybe there were surprise results.” Science says to ask the question, so the researchers did; let’s take a look at the results.

When Meditation Tops Exercise

There were distinct differences between the exercise and stress-reduction groups versus the controls. When compared to the control group, the exercise group had fewer acute respiratory infections. The mindfulness-based stress reduction program also had fewer acute respiratory infections than did the controls, but when looking at other variables such as absenteeism and lost days of work, the stress-reduction program did slightly better than exercise.

When Exercise Beats Meditation

The researchers also examined the total number of infections, and the exercise group did better. In this study, which was completed well before the current pandemic, the exercise group had no coronavirus infections (the common cold) while the meditation and control groups both did; the difference was that the meditation-trained group handled the infections much better than did the controls.

It would have been great if they had one more group that both exercised and used the stress-reduction techniques. It would have been interesting to see if there were additive or even multiplicative benefits, or maybe there would have been no differences or even negative results. We can’t assume that it would have made the immune system function better; the “stress” of doing both might have compromised immune function.

The Bottom Line

Even though this study was done eight years ago, it’s the only study I could find that examined the benefits of exercise related to any type of upper respiratory infection. That the study also included stress reduction/meditative techniques was a bonus. What we know now, based on this study, is that moderate exercise as well as stress reduction will both reduce our risk of serious infection from many types of virus, and we may have milder symptoms if we do catch one. Whether this will serve us well during this pandemic is uncertain, but even a little protection to reduce the most severe symptoms would be worth the effort. That’s great news for people who don’t have the physical capacity to exercise and for those who don’t have the patience for meditation: either one will work. Just do something.

What are you prepared to do today?

        Dr. Chet

Reference: Ann Fam Med 2012;10:337-346. doi:10.1370/afm.1376.

Immune System Training: Exercise vs. Meditation

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What’s going to work better to prevent acute respiratory infections: moderate exercise training or meditation training? Have you predicted which would be more effective without looking at the article? Or do you not have enough information yet? Let’s take a look at what each group did.

The moderate exercise group met for 2.5 hours each week with personnel trained in exercise physiology. The time was broken up into education about exercise and time practicing on different forms of equipment such as treadmills, exercise bikes, etc. The rest of the week, they exercised for 45 minutes per day. Most subjects used walking or jogging as their home modality of exercise. The subjects were trained to exercise at a moderate level based on the Borg perceived-exertion scale; once trained in assessing exertion, it matches up quite well with the effort people are actually performing during exercise.

The meditation group met with personnel trained in mindfulness-based stress reduction techniques for 2.5 hours a week. This program “is based on the idea that an increased awareness of physical, emotional, and cognitive manifestations of stress may lead to a healthier mind-body response to stress.” The subjects were also to practice the stress reduction techniques for 45 minutes every day at home.

The control group did not do either of the techniques. The training lasted for eight weeks. The variables I mentioned in Tuesday’s memo were collected before, during, and after completion of the eight weeks training. What were the results? I’ll give you a little more time to think about it and give you the answer on Saturday.

What are you prepared to do today?

        Dr. Chet

Reference: Ann Fam Med 2012;10:337-346. doi:10.1370/afm.1376.

Boosting Immune Function: Exercise vs. Meditation

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Every once in a while, I come across some research that’s just so interesting and unique, I have to share it with you. In this case, it’s directly related to boosting the immune system, which is what a lot of people are trying to do right now. In this case, researchers tested whether an eight-week program of either moderate exercise or meditation would reduce the variables associated with an acute respiratory infection such as time lost from work.

Researchers recruited subjects who did not get a flu vaccination and also did not exercise or meditate; they used just about every survey related to health that was available. They also took samples from nasal rinses after subjects had acquired an acute respiratory infection of any type and tested for markers of immune function in the rinses.

The mean age of the subjects was 59 years old. The subjects were randomly assigned to one of three groups: the control group who agreed to do nothing during the eight weeks; a group who would exercise at a moderate level; and a group who would participate in a specific type of meditation.

On Thursday, I’ll talk about the training programs. Looking ahead, short of looking up the paper itself, what do you think will be more effective: exercise or meditation to boost the immune system?

Insider Conference Call

Tomorrow night is the August Insider conference call. I’m going to do a COVID-19 update focusing on the recent spate of doctors plugging hydroxychloroquine as well as answering Insider questions. If you become an Insider by 8 p.m. ET, you can participate live!

What are you prepared to do today?

        Dr. Chet

Reference: Ann Fam Med 2012;10:337-346. doi:10.1370/afm.1376.

COVID-19 and Social Media

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A long-time friend and Insider asked if the following were true. I’m going to use excerpts because I don’t want someone to mistakenly think I endorse what’s being said. I don’t, and this Memo is going to point out where the lies exist. I can’t think of a nicer way of saying it because the people who write this stuff are not concerned about your health in the least. Maybe it’s just a bid for attention, I don’t know.

“The Self Test”

From the first social media post (Paula asked me to tell you the copy from social media hasn’t been edited; her appraisal is “Yikes.”):

“The new NCP coronavirus may not show sign of infection for many day. By the time they have fever and/or cough and goes to the hospital, the lungs is usually 50 % Fibrosis and it’s too late! Taiwan experts provide a simple self-check that we can do every morning: Take a deep breath and hold your breath for more than 10 seconds. If you complete it successfully without coughing, without discomfort, stuffiness or tightness, etc., it proves there’s no fibrosis in the lungs, basically indicating no infection.”

The problem with many of these hoaxes is they contain at least one element of truth. COVID-19 may take a few days, maybe up to a week, to begin to show symptoms, generally a fever. The issue is that unless someone already has a fever, the infection would not have spread to the lungs.

There is no self-test that I could find. If it were true, wouldn’t everyone know it by now? (And that’s always a good question when you see health news that’s too good to be true.) More than that, fibrosis doesn’t seem to be the result of getting COVID-19.

“Serious Excellent Advice”

SERIOUS EXCELLENT ADVICE by Japanese doctors treating COVID-19 cases. Everyone should ensure your mouth & throat is moist, never DRY. Take a few sips of water every 15 mins at least. WHY? Even if the virus gets into your mouth…drinking water or other liquids will WASH them down through your oesophagus and into the stomach. Once there in tummy…your stomach ACID will kill all the virus. If you don’t drink enough water more regularly…the virus can enter your windpipes and into the LUNGS. That’s very dangerous.

Drinking fluids is important to your immune system, but there’s no relationship between your ability to drink every 15 minutes and killing the virus with stomach acid. Stop and think: this virus causes problems in the upper and especially the lower respiratory system. If water helps kill it, there are few places in the body more moist than the respiratory system.

“Spread the Word”

Pls send and share with family, friends and everyone about this ! Take care everyone n may the world recovers from corona virus soon. May all be well n happy.

There is always an appeal to share the posts, no matter which form of social media. I would recommend you not do that. These posts are misleading, and if your friends and family follow the advice and get sick… well. You get the point.

The Bottom Line

The medical news during a crisis is difficult enough to follow. Promoting people who post such nonsense slows down the process of educating people on what they really should do to protect themselves and reduce the risk of getting COVID-19. Part of helping others is not passing along incorrect information.

One More Thing

Dr. Chet’s seminar Nutrition for the 21st Century in Atlanta is in just two weeks! Reserve your spot today—when will you get another chance to hear me teach, live and in person? Check it out in the Dr. Chet store. Keep taking your vitamins and probiotics to keep your immune system strong, and I hope to see you there!

What are you prepared to do today?

        Dr. Chet

There’s More to Know About COVID-19

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Someone just sneezed in an enclosed area such as an office or a plane. We know the potential for any virus to be in a droplet, especially if someone is sick. How many individual viruses do you have to inhale to get sick? In theory, just one will do it. After reading more details, it’s likely to take more than that, depending on the virus and with COVID-19, we just don’t know yet.

Are we toast? No, because it gets complicated. It depends on the strength of your immune system, and that includes whether you’ve had a coronavirus from a regular cold that was similar enough to have made antibodies to it. Then the virus has to penetrate cells to replicate; they can’t replicate by themselves. How many cells get infected will, in part, determine whether you get sick or not after exposure. Once the infection begins, your body will produce mucus to try to expel the virus, and thus the potential for infecting others continues, whether you get symptoms or not.

What’s the best thing to do? Keep your immune system strong. Take the supplements you typically use to boost your immune system, and don’t forget the probiotics (check out Immune Boost 1-2-3 on my Health Info page). Get enough sleep. Try to get your stress under control—like that’s easy—but most of us can find at least one stressor to eliminate or postpone, especially now when we have the perfect excuse to cancel. Slow and easy exercise. If you’re starting to feel sick, stay home if you can. If you’re sick and you must leave the house, that’s the time to wear a mask—to protect others. And for goodness sake, wash your hands with soap thoroughly and frequently. That seems to be the universal advice.

What are you prepared to do today?

        Dr. Chet

P.S. This is the last week to get 20% off on The Optimal Performance CD Set and Workbook, so check it out now.

Vitamin C and the Coronavirus

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A long-time reader and Insider asked me to check out an article titled “Vitamin C Protects Against Coronavirus.” It was sourced from the Orthomolecular Medicine News Service. I read it, and I read some of the other blog posts from their website on vitamin C and the coronavirus. They claim to have inside information about how vitamin C is being used via infusion in studies that are starting in China.

The article talked about vitamin C in general and how research shows it can be beneficial against viral infections. There’s some truth to that. However, vitamin C in supplement or IV form has not been proved to be effective against any form of the coronavirus. The article was misleading and was contradicted by the “insider information” because those studies in China have not begun.

I’m sorry to say this is the worst form of scientific misinformation that gets passed around the Internet—no evidence of any kind, just irresponsible suggestions that give people false hope. It doesn’t mean that boosting the immune system isn’t a good idea, but to say that it will prevent or cure the coronavirus just isn’t true.

If you want to boost your immune system, go to the Health Info page at drchet.com and check out “Flu Season: Reducing Your Risk” in the Basic Health Info section. No cures. Just the best science has to say right now.

What are you prepared to do today?

        Dr. Chet

Can Fasting Reduce Inflammation?

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In this Memo, I’ll review the third paper from the recent journal Cell on fasting and summarize what this all may mean for the use of intermittent fasting.

Researchers used both mice and humans as subjects in a series of studies. The objective was to examine how the immune system responded to a fasting protocol. For the study in humans, the subjects fasted for 19 hours after eating, with blood samples taken before and after the fast. In the mice, a variety of protocols were used. The most common was mice were fed for a short time before food was withheld for the remainder of 24 hours.

In mice and humans, circulating monocytes were reduced. This was important because they were pro-inflammatory in nature; thus inflammation decreased in response to the fasting protocol. In some of the studies, this reduction was maintained even with exposure to pathogens. That means the immune response was not compromised even in animals with induced autoimmune diseases.

Fasting Protocols

Three different studies used at least three different approaches to fasting. In the first study, food was withheld completely for 36 hours. In some phases of the second study, calories were reduced by 50% although the vitamins, minerals, and protein were maintained at normal levels. The final study used a fasting protocol we’re most familiar with: eat within a few hours and liquids only the remainder of the day.

The results were similar in sustaining and perhaps improving the immune system of the animals when placed under pathogenic stress. The only issue is what form of dietary restriction worked best? You can’t ask mice how they felt; you can only check immune system markers. In one of the approaches, the skin of the mice was injured at different times of continued fasting. The healing ability continued until the fast went beyond 48 hours; after that wound-healing was impaired.

The Bottom Line

These studies haven’t changed my approach to fasting. If you’re going to fast to rejuvenate your immune system, don’t play games. Reduce caloric intake to 500 to 800 calories per day for two to three days; those studies show the best benefit. Be sure to select small quantities of the healthiest foods.

Fasting is not abstinence. The current approaches to intermittent fasting are really intermittent abstinence. The idea is to abstain from food completely for 12 to 18 hours while still drinking liquids. That may not be possible for everyone. Some medications have to be taken in relation to food intake. Pre-diabetics and type 2 diabetics should still monitor blood sugar, especially if exercising during the fasting times. The current intermittent fasting approach is more about controlling when you eat than anything else, and that’s something you should do anyway.

I believe in fasting. That’s why I wrote Real-Life Detox—so you could do it right and gain the most benefit. The critical thing is to find a way to eat that you can sustain for the rest of your life, and that includes occasional fasts.

Eat less. Eat better. Move more. That’s always the goal.

What are you prepared to do today?

        Dr. Chet

References:
1. Cell. 2019. DOI:https://doi.org/10.1016/j.cell.2019.07.047.
2. Cell. 2019. DOI:https://doi.org/10.1016/j.cell.2019.07.049.
3. Cell. 2019. DOI:https://doi.org/10.1016/j.cell.2019.07.050