Tag Archive for: muscle

What Is the Proteome?

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In the week we took off, I spent my time researching a couple of fascinating studies. We all have different ideas of what’s fun, don’t we? For me, getting to research topics in depth is a refreshing opportunity to learn something new. I’m going to share part of what I learned in the next several memos and it’s all about the proteome.

Obvious question: what is the proteome? A proteome is the complete set of proteins expressed by an organism—same idea as the microbiome, but with proteins instead of microbes. That includes obvious proteins such as muscle, hormones such as insulin, or many of the thousands of enzymes and other proteins the body makes. Those proteins may be produced only during specific circumstances and in response to events within and outside the body. The proteins can be systemic or they can occur in individual tissues and cells.

More than what, why is the proteome important? Research has demonstrated that there’s variability in the proteome at specific times during life. The idea is to identify which proteins change and which ones are associated with a healthier life. That’s the first step and I’ll cover a study that did just that on Saturday.

Tomorrow is the monthly Insider conference call. Check out the membership and if you become an Insider before 8 p.m. Wednesday, you can take part.

What are you prepared to do today?

        Dr. Chet

Reference: Aging Cell. 2018;17:e12799. https://doi.org/10.1111/acel.12799

Should You Take Essential Amino Acids Before Surgery?

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Tuesday’s study left us with a question: what could explain essential amino acids (EAAs) increasing, or at least preventing, muscle loss after total knee replacement surgery? Fortunately, another study examined those factors by obtaining muscle biopsies and blood before and after surgery.

Researchers recruited 41 patients who were having total knee replacement. After randomly assigning them to placebo or experimental group, the experimental group received 20 grams of EAAs twice daily, beginning seven days prior to surgery, until six weeks after surgery. Those in the placebo group were given nonessential amino acids. Muscle biopsies were collected from all subjects the day of the surgery and again either one or two weeks post-surgery with the determination made randomly. Blood was also collected for analysis at the same times as the biopsies.

The researchers found that the subjects taking the EAAs had a significantly increased amount of satellite cells, also known as muscle stem cells that can develop into muscle cells, compared to the placebo group; the ability to build muscle faster could help the recovery process. IL-6 and TNF-alpha were elevated post-surgery in both groups; however TNF-alpha declined by two weeks post-surgery in the EAAs group, which meant inflammation decreased. Based on the changes in cytokine production, inflammation after surgery decreased faster with EAAs than it did in the placebo group.

The researchers concluded that taking the EAAs seven days before surgery increased satellite cells on the day of surgery and promoted a more favorable inflammatory environment post-surgery. That could mean a quicker recovery from surgery and benefits during post-surgical rehabilitation.

The Bottom Line

While there’s more research necessary, I think the use of EAAs before and after knee replacement surgery is helpful. I would extend that even further; I think that EAAs may ultimately prove to be beneficial before and after any type of surgery. In almost every case, muscle tissue is going to be cut and thus will need to repair itself. We don’t know the benefits of EAAs on other connective tissue such as skin and ligaments, but because we’re targeting the key elements of protein with the EAAs, there’s little to no chance of any harm.

Based on these two studies, I think that 10 to 20 grams, spread out in two doses per day, would be the best approach. One important point: take the EAAs 15 to 30 minutes before eating anything or before working out. Those were the protocols used, and it’s the same that I recommend in Aging with a Vengeance for increasing muscle mass as we age.

I’ll be honest: it tastes weird. But I made sure Paula took EAAs before and after her recent carpal tunnel surgery, so you know I think it’s worth the effort.

What are you prepared to do today?

        Dr. Chet

Reference: J Appl Physiol (1985). 2019 Aug 1; 127(2): 531–545.

Improve Your Posture

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Today is the final post about the physical factors of living and not just being alive, and it’s about your posture, the way you carry yourself. Posture reflects the interplay of your skeletal, muscular, and nervous system: the way you stand, the way you move, and the way you sit. Those all rely on the interaction of the three systems. The key is that we have to train those systems to consciously respond to the way we want to stand or sit until they become automatic.

I was overweight as a kid. One of the things I did was hold my stomach in so I didn’t appear to be so fat. It stuck. I don’t know what it’s like to relax my abs because it seems unnatural to do so. Here’s a secret: you can look five to ten pounds lighter just by holding your abs in and your shoulders back. You also can be taller by training your core to keep your stomach in and training your shoulders to hold your head erect.

There’s a lot going against us. Sofas are soft to sink into, and we do. Even our car seats can make it harder to hold our shoulders back. We are always looking at our cell phones, so we see teens developing the cell-phone hump, which looks a lot like the dowager hump. And even if we stand or sit straight, it may all fall apart when we work or exercise. Do you bend at the waist to pick up a package? Do you run hunched over? Especially when you lift weights, it’s important to get the posture correct so you’re training the correct muscles in the correct movement; that’s why it’s good to have a trainer or physical therapist to help you get started. And by the way, that’s the real reason for the walls of mirrors at the gym.

How do you stand tall? Sit tall? Practice. Once you get the correct posture, you have to keep practicing it until it becomes automatic. We have to fight our nature to slouch standing or sitting. You just have to keep practicing until it becomes automatic. It can impact just about every organ in your body, including your bones. That’s where we’ll pick this up next week.

What are you prepared to do today?

        Dr. Chet

How Flexible Are You?

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Living every day you’re alive requires flexibility. Range of motion in your joints is important to your ability to move, but it can be difficult. As the years add up, touching your toes with your knees locked, whether sitting on the floor or standing, lifting your arms over your head, or even lifting your arms to shoulder level can be a challenge.

Connective tissue tends to tighten as we age; it’s another case of use it or lose it. And when I say age, I mean from teen years on. Later, after we’ve torn ligaments, sprained ankles, been in accidents, and on and on, if we haven’t worked on our range of motion, we can end up restricted in our ability to move. The less we move, the more restricted we can get.

The obvious way to increase flexibility is to stretch. There are dozens if not hundreds of programs online, but I would recommend that you get an examination by a physical therapist who can identify your strengths and weaknesses and prepare a program just for you, taking into account your current level of flexibility and previous injuries. The older you are, the more strongly I recommend physical therapy, because if you stretch too far and damage connective tissue, you’ve just made your situation worse. Another option, especially if you’re younger or more fit, is to try yoga, which is an overall muscle-strengthening and stretching program. Take a class with an experienced instructor so you can get feedback on whether you’re doing the movements correctly.

Stretching is something you should do every day. There’s one area that needs special attention and that’s your core. I’ll cover that on Thursday.

What are you prepared to do today?

        Dr. Chet

Preventing Muscle Loss

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This final installment on muscle focuses on keeping the muscle mass you’ve got. That’s one of the keys to living every day you’re alive: the ability to move at every age. There are three things that are important to hanging onto muscle.

  • Use it or lose it. Actually, you’re going to lose it not matter what, but the degree to which you will is partially dependent on using it. Whenever you can take the stairs, take them. Whenever you can lift something, lift it. While I would hate it personally, it was better when we had to get up and actually walk to the television to change the channel. More today than ever, we don’t take the opportunity to build muscle or increase stamina.
  • Exercise regularly. No matter your age, there’s always something you can do. Orthopedic issues happen as we get older—arthritis in hands, shoulders, hips, and knees, or torn ligaments and cartilages. They can all put limitations on what we can do. We have to work within those restrictions and do as much as we can to maintain and even increase what we have. A session with an excellent physical therapist (ask your doctor if you qualify for some free sessions) or certified personal trainer could be worth the money. It’s never too late to begin. Research has shown that even people over 100 years old can increase strength and stamina.
  • Consider taking essential amino acids every day. While the focus has been on what EAAs can do for people who train hard, the bulk of the research has been done on people 50 and older. It’s clear you can slow down muscle loss and increase muscle strength by exercising regularly and taking EAAs every day. I’ve been taking them the days I lift, but I’m considering taking them every day. In continuing to research the benefits, there doesn’t seem to be a downside to taking EAAs. There’s some preliminary research that indicates that taking EAAs may even be beneficial for pre-diabetics to reduce insulin levels and triglycerides if they exercise regularly as well.

The purpose for the month’s Memos is showing you how to learn to live every day you’re alive. Muscle is critical to that goal. We’ll move on to another important physical component of living next week.

What are you prepared to do today?

        Dr. Chet

Skeletal Muscle: Strength

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This week, we’re turning our attention to skeletal muscle. Skeletal muscle allows us to move and to lift ourselves and other objects. The two primary features are strength and stamina. Let’s begin with strength.

A simple definition of strength is the most weight you could lift once. That could be as little as a couple of pounds, or it could be as much a thousand pounds as some weight lifters have done. To me, as a minimum, strength is the ability to be able to do everyday tasks. We’ll start with the most fundamental, which would be sitting down in a chair or on a commode and then having enough leg strength to stand up. It would be enough to be able to lift a bag of groceries. To lift a hammer to hit a nail. To hold a hair dryer over your head while you do your hair. You can probably think of a few more.

Years ago, I mentioned to my mother-in-law that most women over 65 can’t lift 10 pounds. We lose strength as we age. She had just gotten back from grocery shopping and she picked up a 10-pound sack of flour. She began lifting it up over her head and back down to her lap and said, “Look Chet, I can do that!” She was in her mid-seventies at the time.

Strength can vary by body joints. With two torn biceps, I don’t have nearly the strength in my arms and shoulders as I used to, but I still have pretty good leg strength and pretty good back strength; my exercise routine includes strength training for all those areas.

How do you increase strength? Challenge the muscles to lift more weight than you currently can for any different set of muscles: your shoulders, your arms, your quads, your calves, and of course, there’s your core. I’ll save that for later in the month. Next time, we’ll take a look at muscular stamina.

What are you prepared to do today?

        Dr. Chet

The Bottom Line on Essential Amino Acids

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Essential amino acids are becoming more prevalent in the sport nutrition supplement offerings. Yet there are still questions that remain, and we don’t have a total picture of who will benefit from EAA use. Let’s take a look.

Questions

Even with this new research, there’s so much we still don’t know about EAAs.

  • Is there a special proportion of EAAs that works best? In other words, should the amount of leucine or isoleucine or tryptophan be higher than other EAAs? What’s the best proportion?
  • What’s the best source? Milk, which contains whey and casein? Soy? Rice? Pea? Or a form of meat such as chicken, fish, or beef?
  • Do the EAAs compete for absorption? Does eating a complete protein such as the protein in beef or chicken inhibit the absorption of the EAAs in the protein? After all, just eating more meat could potentially be the best solution, but maybe it’s not as efficient as getting the EAAs in a stand-alone product.
  • How much muscle will athletes build in how long a time? Will it be 1% or 5% better than just eating more protein or will it be the same?
  • Should the EAAs be taken alone or as part of a protein shake?
  • When is the best time to take the EAAs in relation to a workout? Or does it really not matter? What about other nutrients taken at the same time such as carbohydrates or fats? Will they positively or negatively impact the EAAs?

There are some partial answers in the research but nowhere near enough to say “This is how you do it for the best benefit.” That’s not to say that there are no opinions, but it’s based more on limited research or personal experience than anything else.

The Bottom Line

Based on all of the available information, here is the bottom line on EAAs.

  • Everyone needs more EAAs in their diet, especially those of us over 50. (We all need to do more resistance exercise, but that’s a different Memo.) It’s more than just losing muscles mass as we age; it’s also about being able to make all the hormones we need for optimal health.
  • Eat about one gram protein per pound of body weight up to about 150 grams per day. If someone is overweight or oversized, trial and error is the only way to set an upper limit. But it’s critical for athletes and older people to hit that mark. Chicken seems to be the best profile for EAAs next to milk protein, but there’s more research needed.
  • If you get your EAAs from powders, whey protein isolate seems to have the best profile based on the content of branch-chained amino acids, but soy protein has a good profile as well. There doesn’t seem to be a perfect source yet.
  • If you want to take a separate EAA product that has no other amino acids, that’s fine. It will probably be best to take it before you work out or lift weights, but there’s good reason to take it after working out as well. About 15 to 30 minutes later, take your complete protein, whether from powders or food.

As research continues, I’ll update the recommendations as we get more answers. For now, make sure you get enough protein for health and growth based on what we know today.

What are you prepared to do today?

Dr. Chet

 

Essential Amino Acids for Older Adults

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One of the issues we all face as we get older is the loss of muscle mass; the technical term is sarcopenia. While some of the loss can be attributed to declining hormone levels as well as the decline in physical activity, we tend to eat less protein as we get older. Less protein intake means less muscle and other protein synthesis.

Researchers in Japan wanted to see if increases in muscle mass were related to protein intake, specifically EAAs. Instead of jumping right into supplementing with EAAs, they recruited 10 older men with a mean age of 69 and gathered nutritional information using a three-day dietary record. They put the men on a progressive weight training program, lifting three days per week for 12 weeks.

All men gained muscle mass, about one pound of muscle per leg. In analyzing the diet, the average protein intake was 99 grams of protein per day with 37 grams from EAAs. What they found was that those men with higher EAA intake, especially leucine, had a greater increase in muscle mass. It was even better if they had the EAAs with their breakfast.

This was a small preliminary study that examined current food intake with no intervention other than exercise. It may indicate that in order to be efficient at adding muscle mass, EAAs are important in older adults. What does this mean for you if you’re in that age group or an athlete wanting to add muscle mass? I’ll let you know on Saturday.

What are you prepared to do today?

Dr. Chet

 

Reference: J Nutr Sci vitaminol (Tokyo). 2017;63(6):379-388. doi: 10.3177/jnsv.63.379.

 

Essential Amino Acids: The Basics

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I’ve been getting many questions about essential amino acids lately. What are they? Why do I need them? Are they only for athletes? What can they do for me? In addition, I came across an interesting study that supports the use of EAAs in a specific population.

The EAAs include the amino acids phenylalanine, threonine, tryptophan, methionine, lysine, histidine, leucine, isoleucine, and valine. They’re essential because we can’t make them, but we can make other amino acids from these EAAs. In addition, three of the EAAs are designated as branch chain amino acids (BCAAs): leucine, isoleucine, and valine; they’re known as protein-building amino acids and important for building muscle.

Think of the EAAs as the rate-limiting amino acids. If we don’t have enough of them, we can’t make the other amino acids and thus, every protein made in the body can be affected. We often think only in terms of muscle, but the lack of EAAs could affect the manufacture of insulin, human growth hormone, leptin, and adiponectin to name just a few.

BCAAs have been marketed to athletes who are training to make muscle for years. Recently, EAAs have entered the arena because of their ability to make proteins that support muscle building. But that’s not the only group that may benefit as a recent study demonstrated. I’ll cover that on Thursday.

What are you prepared to do today?

Dr. Chet

 

Research Update on Sarcopenia

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We know what sarcopenia is, but what can be done about it? Recent research may give us a clue.

Researchers in the United Kingdom examined a variety of variables related to sarcopenia in a group of men. Remember, a motor unit is a nerve and all the muscle fibers to which it attaches. They looked at the differences between the size of the motor units and the total units between 48 young men, 13 non-sarcopenic elderly men, 53 pre-sarcopenic, and 28 sarcopenic men.

The motor unit potential was greater in non-sarcopenic and pre-sarcopenic men than in young men. Why would that be? The researchers suggested that the nerves are still sending out nerve shoots trying to recruit more muscle fibers. This was not the case with the sarcopenic men; their motor unit potential was much lower. That could mean that once connections are lost, there’s no way to recover muscle function including strength.

While the researchers could not answer that final question with certainty, it’s apparent that preventing potential motor unit loss is critical. How? We’ll talk about that on Saturday.

What are you prepared to do today?

Dr. Chet
Reference: J Physiol. 2018 Mar 11. doi: 10.1113/JP275520.