Tag Archive for: aging

Lifestyle, Activity, and Aging

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Here’s the question: if the subjects with the highest leisure-time physical activity (LTPA) lived longer, why did those subjects age faster based on the tests used in the study? The answer is complicated.

Exercise and Longevity

The researchers analyzed the data several ways. In the first analysis, they adjusted the data for sex, age, and health status; that makes sense because we know those factors impact longevity independent of exercise. Then they adjusted for education, body mass index, smoking, and alcohol use.

The first model was as expected with a continuing decrease in rate of death as physical activity increased. But when the other factors were included in the analysis, the hazard ratio (risk of dying) dropped from 23% to the reported 7%. What does it say in simple terms? If you smoke, drink a lot of alcohol, or are overweight or obese, exercise can only do so much. In short, your lifestyle matters.

Biological Aging

Taken from the paper’s text:

“Biological aging is the gradual and progressive decline in system integrity that occurs with advancing age and results in increased risk of morbidity and mortality. Epigenetic clocks produce estimates for biological aging based on DNA methylation (DNAm) alterations within specific locations in DNA sites and are one of the primary hallmarks of biological aging.”

The blood tests used two biological aging “clocks” based on the subjects’ DNA. They found that those who were the most active had a similar aging pattern in their DNA to those who were sedentary. That’s why the headline said high levels of LTPA increased aging.

What they couldn’t explain was why. They defined high levels of physical activity as ranging from fast walking to competitive running—that’s a pretty wide range. Does high LPTA damage those areas of DNA more? Why would it be similar to being sedentary? It lends itself to examining the measurement used for the test and to future research on other factors that may play a role, such as nutrition.

The Bottom Line

The paper provides insight into the importance of physical activity in our lives. What needs further examination is why high levels of physical activity would result in damage to DNA that mimics someone who is sedentary and raises the question of whether excessive exercise has a negative effect. As unusual as it would be to say someone exercises too much, it’s possible, and it could be more harmful as we get older. But it’s important to note that only 5% of the subjects had biological aging tested, so the sample size is small considering the follow-up was 30 years.

The real message? Physical activity isn’t enough to overcome a poor lifestyle. The damage caused by excess weight, smoking, and alcohol use can’t be overcome by exercise alone, even at high levels of physical activity. It still comes down to what I always say: Eat less. Eat better. Move more. That’s a great place to begin.

What are you prepared to do today?

        Dr. Chet

Reference: https://doi.org/10.1101/2023.06.02.23290916

How Exercise Affects Aging

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If a headline says, “exercise could make you age faster,” you know I absolutely must read it. There were a variety of commentaries on an unpublished study by Scandinavian researchers who won the Finnish national sports medicine prize; an advanced copy was published in PUBMED.

Researchers used data collected from an ongoing twins study with close to 23,000 twins who were 18 to 50 years old when the study began in 1975. The variables they used were leisure-time physical activity (LTPA) collected via questionnaires, self-reported height and weight, smoking and alcohol use, as well as education level. The data were collected from one to three times on the subjects; researchers also collected blood samples on 1,153 twins over the years as well. They gathered the samples to determine biological measures of aging using epigenetic clocks, biochemical tests that can be used to measure age. Their primary outcome measure was mortality, both in the short term and long term.

What did they find? As I would have expected, as LPTA levels increased, all-cause mortality decreased. But was it as simple as that? That doesn’t fit the headline. There’s more, and I’ll cover it on Saturday.

Speaking of what I’ll cover, on tomorrow’s Insider conference call the topic will be V.O.M.I.T. as well as answering your questions (including what V.O.M.I.T. is). You don’t want to miss this one, so give yourself a healthy Christmas gift and become an Insider by tomorrow at 8 p.m. ET.

What are you prepared to do today?

        Dr. Chet

Reference: https://doi.org/10.1101/2023.06.02.23290916

More Taurine, Longer Life

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The researchers next step was to supplement the diet of several species with taurine to see if the lifespan of various species would be increased. While they didn’t include humans in the study (we live too long), they did note in other studies that some factors related to aging declined with taurine supplementation.

Taurine supplementation significantly increased the lifespan of worms, mice, and rhesus monkeys, but researchers didn’t determine the originating mechanism involved in the protective process. Certainly, genes have to be impacted in some way, but the only conclusion they could make is that supplementing with taurine extended the lifespan of the species tested.

Combine that with the decline that occurs with aging in humans and the associated increase of degenerative conditions, and it appears that taurine is critical for improving human health as well decreasing some of the manifestations of aging.

Increasing Taurine Intake

The only real question is the best way to increase taurine levels. Would there be any downside to taking a taurine supplement? Or should we focus on increasing the protein in our diet, specifically the animal protein? Here’s something else to consider before we get to that point: one of the characteristics of aging is a decrease in protein intake. There’s no reason that I could find for that to happen. It just does.

I think it should be a combination of both sources. Protein intake should be increased once a person reaches 50 to at least one gram per kilogram body weight. That would mean it would be roughly half a person’s body weight in grams. If you weigh 200 pounds, you should probably get 100 to 120 grams of protein per day. It may be prudent for those over 70 to exceed that amount, not just for the taurine but also to stem the loss of muscle mass. It may require a concerted effort to eat that much protein.

Let’s turn to taurine supplementation. Taurine is typically offered in 500 milligram capsules. When you look at the research, the amount used in studies ranges from 500 milligrams per day up to six grams per day. A couple of studies lasted at least six months long. Taurine supplementation seems safe.

Starting with one gram of taurine per day for a minimum of 60 days is a good place to begin. Depending on where you began, you may or may not feel anything, so you can increase the amount. Or you may find it’s having a profound effect on you because it impacts so many different organ systems in the body, and you may decide to hold the line.

How about your diet? What foods contain taurine? The highest taurine levels would be found in shellfish, eggs, soy products, and liver as well as—surprise, surprise—energy drinks if you want to use them. But don’t forget, all animal protein will count because it will have the two primary amino acids that taurine is made from: methionine and cysteine.

The Bottom Line

Is taurine the fountain of youth? No. But it’s one of many strategies we can use to age well. Living long is not good enough. Living well longer should be our goal. Increasing taurine levels is another step in aging with a vengeance.

What are you prepared to do today?

        Dr. Chet

Reference: https://www.science.org/doi/10.1126/science.abn9257

Taurine’s Effects on Aging

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A recent research paper examined the amino acid taurine and its connection to aging; in fact, the title of the research paper is “Taurine as a Driver of Aging.” It was published in the journal Science in June 2023; it’s open access if you’re interested in reading the article itself.

Taurine is a sulfur-containing amino acid that can be made from the amino acids methionine or cysteine metabolism. It plays a role in several essential body functions, such as regulating calcium levels in certain cells, manufacturing bile salts, balancing electrolytes in the body, and supporting the development of the nervous system. There is one more way that taurine may benefit us: taurine appears to be important in mitochondrial health as well. And when you think mitochondria, think energy.

In the first part of the study, the researchers examined taurine levels at various ages during the lifespan of several species. They looked at mice, macaques, worms, yeast, and human beings. The results were absolutely clear: as these species got older, the taurine levels decreased substantially. While all species had other metabolic functions going on, the stark drop in taurine certainly appeared to be related to the decline of many body systems.

But how do you test that? You supplement the diet of the particular species with taurine. That’s what the researchers did, and I’ll tell you what happened on Saturday.

What are you prepared to do today?

        Dr. Chet

Reference: https://www.science.org/doi/10.1126/science.abn9257

How Fasting Impacts Your Mitochondria

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The research scientist in the webinar focused on mitochondria and aging in his part of the presentation. He has helped research and develop a nutrient that appears to help with mitophagy, the process of removing and replenishing old mitochondria. The naturally produced chemical is called urolithin A. It’s produced naturally by the microbiome in response to eating foods such as fruit, especially pomegranate, and nuts. The problem is that we may or may not produce enough urolithin A, depending on the state of our microbiome. There has been decent research on the supplement, and I talked about the supplement in Aging with the Vengeance: Reclaiming Your Power.

What caught my attention was that intermittent fasting may also help with renewing and replenishing mitochondria. The problem becomes what kind of fasting are we talking about? Complete fasting? Eating during only a few hours per day? I’ll cover the two most popular forms.

Intermittent Fasting

Intermittent fasting is “in” right now. It is especially popular when combined with the Paleolithic or the ketogenic diet. What it essentially means is that you take in no calories by mouth for up to 20 hours per day, often called the 20:4 approach, and then you eat during that four-hour block of time. Research has shown that people lose weight, get better control of their prediabetes, and may even reduce some of the metrics related to cardiovascular disease such as blood pressure and cholesterol levels. But specific to mitochondria, the data are nowhere near as clear.

Fasting Mimicking Diet

I first encountered the fasting mimicking diet, or FMD for short, when I looked at the research of Valter Longo. He’s a scientist who has used periodic fasting with patients undergoing cancer treatment. For one to five days before treatment, they go on an FMD which drops down to 500 calories per day in some cases, and then they go back to their regular diet and go through their normal chemotherapy protocol. The critical factor is that he’s shown an improved quality of life as well as improved outcomes for people who used the FMD during treatment as opposed to those who ate their normal diet.

In research in mice, using FMD has demonstrated a reduction in symptoms of Alzheimer’s disease and dementia. Parkinson’s disease, obesity, type 2 diabetes, and others have also benefited from the FMD approach. Dr. Longo has created a commercial program that is available.

Why FMD? As near as I can gather, the concept utilizes the body’s protective mechanisms that allow energy to continue to be produced at a high enough rate to continue carrying on with life (such as searching for food in other eras) in the absence of food until food can be found. Research in athletes who’ve used FMD versus a normal diet has demonstrated maintenance of strength and endurance after going through a five-day FMD protocol while continuing to work out.

The Bottom Line

In my opinion, FMD makes sense. Fasting for two days and then going back to your normal diet for a couple of weeks just makes more sense than obsessing about when you can eat every day. But you may feel intermittent fasting’s a better way to go for your life, and that’s fine as well. One thing for sure is that I’m going to continue to follow this research.

The whole point to this is that restricting calories for long blocks of time stimulates the body to take good care of our mitochondria; that’s one battle that we have to win if we expect to age with a vengeance. And the great thing is that you can begin at any age.

What are you prepared to do today?

        Dr. Chet

Aging Stressor: Excess Body Weight

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The last major stressor that comes with age is excess body weight. The first book that I ever bought in grad school was about obesity. In it, there was a chart of almost 100 health issues that were linked by research to carrying extra body fat and one that was not. In the 40 years since then, the list of negative effects of obesity has grown.

If you remember my answer to the question from last week’s Memo about what one thing would I do differently in my life, that’s the reason I chose getting to a healthier weight and staying there. Pick a body system, any system, and you’ll find the deleterious impact of excess fat on that system. Immune system? Yes. Joints? Yes. Liver? That too. Pancreas? Yes—and on and on and on. That’s why it’s important to get to a healthy weight as young as you can and stay there.

But what about now? It’s been a 50-year fight for me, and I still have not succeeded to the extent I would like. Getting to a healthy weight is not about a specific diet or foods or anything other than one thing: the quantity of food we eat.

I’m going to give you the simplest approach to losing excess body fat I can with two ways to do it.

  • Use a smaller plate when you eat meals and fill it only once. Moving from a dinner plate to a salad plate will cut off about 20 to 25% of the calories you eat. You can use the same logic with smoothies or cereal or soups. Smaller portions yield fewer calories.
  • As an alternative, reduce your caloric intake by 250 to 500 calories per day if you already track your food intake. That’s it.

Can you work on the quality of food? Sure. How about fewer carbs or less fat? If you want. What I’m saying is that to attack the excess body weight you carry, you have to attack your number of calories and eat fewer of them. Start with the sledgehammer to break down the wall. You can get to the chisel later on to fine-tune your lifestyle.

That one benefit of being overweight? It reduces the risk of osteoporosis. I don’t think that’s worth the hundreds of other risks it increases.

Aging with a Vengeance

The first Aging with a Vengeance webinar will be on Super Bowl Sunday; the topic will be increasing muscle mass. I’ll be covering a specific strength training program together with nutrition approaches including diet and supplements. The approach is based on the practical application of the most recent research. The first Memo of 2023 will give details on how to sign up for the webinar and the materials you’ll get.

Have a Very Merry Christmas from all of us at DrChet.com! Talk to you again on January 1, 2023.

What are you prepared to do today?

        Dr. Chet

Aging Stressor: The Muscular System

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Sarcopenia is the number one issue that impacts muscles—that’s the loss of skeletal muscle mass and strength that comes with age. It can begin as early as the 20s in some and accelerates once we pass 60; it’s thought to be primarily due to the genetics of aging. There’s also little question that a sedentary lifestyle contributes to muscle loss. Losing muscle mass impacts not just strength, but also stamina, posture, balance, and the ability to move your body.

There are several types of muscle fibers, but they all appear to become slow-twitch fibers as we age. And they get smaller. However, and this is important, they don’t ever seem to go away completely. Strength training has been shown to be effective even for people who are 100 years old; they get stronger, which helps deal with all those issues I mentioned before. The research hasn’t demonstrated that muscles will get larger, but most studies end at three to six months, which is too soon to really judge results; it’s probably going to take more than six months to gain back what we lost over many decades.

The key to dealing with sarcopenia is strength training—the earlier in life the better, but it’s never too late. Strength training can encompass many approaches from doing squats by standing up from sitting in a chair (using a walker if balance is an issue), push-ups and other calisthenics, and weight training using bands, tubes, machines, and free weights.

There are hundreds of programs and thousands of exercises to help build strength using every modality. I think it should all begin with an evaluation by a healthcare professional to test posture and balance, as well as strength. The next step is to see a physical therapist who can evaluate your limitations and put together a plan to get you started safely; it’s hard to keep your positive attitude if you get hurt right away and need to pause. Once you get approval and a plan to train, then getting muscles prepared is important. Calisthenics, which include chair exercises for those with arthritis, are a good place to begin.

Final memo before Christmas on Tuesday with one more place to attack when we’re aging with a vengeance.

What are you prepared to do today?

        Dr. Chet

The Stress Response

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Anyone who studies the stress response will be familiar with the general adaptation syndrome (GAS) that’s depicted in the graphic. The response was developed by the Canadian scientist Dr. Hans Selye over years of experiments; his research focus was the hormonal response to chronic stress. To promote his adaptation concept, Dr. Selye was just as good a marketer as he was scientist. Although we know a lot more today about the hormonal and neural responses to stress, the GAS still applies to chronic stress for the most part.

Stress, both acute and chronic, is going to happen—it’s inevitable. What matters is how we respond to stress. After 35 years as an exercise physiologist, I know there are two ways to prepare for stress of all kinds: exercise and mental preparation.

Exercise

Like the concept of fighting fire with fire, you can fight stress with exercise, which is a stressor. If you examine the hormonal and neural response to exercise, it’s the classic response. (If you want to read more about the particulars of the stress response, please go to reference 1.) What makes exercise different is that we can increase our resistance because we control the amount and intensity of that stress; or in terms of the GAS graphic, we can gradually move that white line up higher.

The side benefit is that it can help when we are exposed to other types of stress as well. For example, while we may still be disrupted by the hustle and bustle of the holidays, it will not have the same impact on our immune or cardiovascular system. There’s no better way to be prepared to deal with stress than regular exercise, and it helps to prepare your mind as well.

Mental Preparation

There are dozens of ways to prepare your mind for how you respond to the stress of life; there are courses to take, books to read, positive affirmations to say, and other techniques such as prayer and meditation. But here’s the thing: you never really know how you’ll respond to stress until you’re exposed to it. There’s a big difference between someone taking your parking space and getting a cancer diagnosis. One is over in a few seconds while the other may alter your life in many ways.

The way your mind responds will also be impacted by prior experiences, both positive and negative. You have to call upon how you responded in the past to know the best way to respond when you face the same or similar stressors. It would certainly help if you had some warning when the stressors would show up.

Aging Causes Stress

Aging is one of the major stressors we face. To get an idea, read the material in the second reference. Near the end of the article, you can read the impact of aging on every organ and system in the body. We can’t stop aging, but we can prepare for it. Remember what I said about when stressors would show up? We have a pretty good idea when that will happen with aging, so we can work to reduce the impact on our bodies. That’s what Aging with a Vengeance is all about. In the next few Memos, I’m going to tell you those areas I think we can impact the most as we age.

What are you prepared to do today?

        Dr. Chet

References:
1. https://www.ncbi.nlm.nih.gov/books/NBK541120/
2. https://medlineplus.gov/ency/article/004012.htm

Metabolism Across Our Lifespan

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It might not surprise you to learn that adjusted for body weight, infants under one year have the highest metabolism of all age groups. It makes sense; they’re growing so fast at that point. From there it’s all downhill, metabolically speaking, at a rate of about 3% per year until about 20 when metabolism stabilizes. The lowest metabolism? We reach that sometime after 60. If we live to 90, researchers found that caloric needs declined by 26%.

That’s the “what.” More important is the “why”; researchers had some but not all of the answers.

Metabolism and Life Events

Researchers examined metabolism during adolescence. The expectation is that metabolism would increase during this period of growth, but they found that it didn’t change significantly.

There was also no significant increase in metabolism during pregnancy, at least, more than what was expected. In Healthy Babies, I talk about the caloric needs of pregnant women by trimester. Those caloric needs prove to be spot on. Sorry, but there’s no need to eat for two.

One more point: carrying extra fat results in an increase in metabolism. That makes sense because every extra pound means the muscles work harder in moving the weight, the heart pumps harder because there are more blood vessels, and so on. But when extra body fat is accounted for, there’s no difference in metabolism on a pound-for-pound basis.

Why Does Metabolism Decline?

Why does our metabolism start to decline faster at around 50 or 60? One factor is the loss of muscle mass; that’s why it’s so important to increase muscle mass and hang on to it as we age.

This study measured caloric use over 24 hours, so the age-related decline in physical activity may play a role in why metabolism declines: most of us are much less active over 50.

But one of the many researchers involved in the projects stated it this way: the reason for the decline in metabolism is that “cells are slowing down.” He went on to say that these changes occur in ways we don’t yet understand. Do the cells get tired? Have a harder time with cell division? Or are there some as yet unknown signal chemicals that are controlling the aging mechanisms that impact metabolism? We don’t know yet.

The Bottom Line

One study is not enough to find out all the answers to what happens to metabolism as we age, but it does provide some insights in where we can look to find the answers. One area that might be interesting is the mitochondria, the powerhouse of the cell; what happens there impacts our ability to make energy and that can definitely impact metabolism. We’ll keep an eye on this research as time goes on.

What are you prepared to do today?

        Dr. Chet

Reference: Science 13 Aug 2021. 373 (6556):808-812. DOI: 10.1126/science.abe5017

What Happens to Our Metabolism?

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Have you ever said or heard someone else say, “I could eat whatever I wanted when I was young and I never gained weight!” What usually follows is something like, “Now I seem to gain weight just by thinking about a donut!”—the type of food may vary depending on the individual. Kids seem to eat anything they want and stay rail thin. Riley grew five inches between his five-year and six-year physicals but gained only three pounds. The logical question is what happens to metabolism as we get older?

Researchers in the Pennington Biomedical Laboratory attempted to find out together with researchers from around the world. As a combined effort, they recruited over 6,000 subjects between the ages of six months and 95 years old. The reason they needed so many research facilities is that the technique used to assess metabolism is labor intensive; it would have taken a decade for a single facility to do it. They didn’t test only resting metabolism. They were able to test the metabolism of subjects over several days under a variety of everyday conditions—in other words, people just living their lives.

There was no surprise from the aging perspective: metabolism declines as we get older. But when metabolism peaks and when it declines the most was surprising. I’ll cover that on Saturday as well as what we might be able to do to deal with it.

Tomorrow night is the Insider conference call. If you have questions you need answered about nutrition, supplements or exercise, this is the forum to get the most complete answers. If you’re not an Insider, join before 8 p.m. Eastern to participate.

What are you prepared to do today?

        Dr. Chet

Reference: Science 13 Aug 2021. 373 (6556):808-812. DOI: 10.1126/science.abe5017